常见病毒引起的淋巴细胞抗原性质变化。
Changes in antigenic nature of lymphocytes caused by common viruses.
作者信息
Thompson E, Lewis C M, Pegrum G D
出版信息
Br Med J. 1973 Dec 22;4(5894):709-11. doi: 10.1136/bmj.4.5894.709.
Healthy human lymphocytes were incubated in the presence of influenza A2/Singapore/57, herpes simplex type 1, or adenovirus type 2. After two days the cultures were inactivated by irradiation. Fresh lymphocytes taken from the same donor were then found to react to the virus-treated cells in short-term cultures. We suggest that this reactivity is due to a change in the surface characteristics of the lymphocytes brought about by the presence of the virus. This may account for anomalous reactions in mixed lymphocyte cultures, and a similar effect in vivo might cause accelerated graft rejection.
将健康人的淋巴细胞与甲型流感病毒A2/新加坡/57、单纯疱疹病毒1型或腺病毒2型一起培养。两天后，通过辐照使培养物失活。然后发现，取自同一供体的新鲜淋巴细胞在短期培养中会对经病毒处理的细胞产生反应。我们认为，这种反应性是由于病毒的存在导致淋巴细胞表面特征发生了变化。这可能解释了混合淋巴细胞培养中的异常反应，并且体内的类似效应可能会导致移植排斥反应加速。
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