Bartman C D, Campbell I M
Can J Microbiol. 1979 Feb;25(2):130-7. doi: 10.1139/m79-021.
The naphthalenones asparvenone and its 6-O-methyl ether are produced by Aspergillus parvulus during vegetative growth in batch-mode, shaken cultures in a glucose-glycine-salts medium. The secondary metabolites first appear around the time when hyphae of developing spores begin to make contact with each other, i.e. at a very early stage of culture development. Resuspension in new medium of mycelium that is producing the naphthalenones fails to inhibit production. When A. parvulus is grown in parallel on a glucose-glycine-salts medium and on a glucose-malt-peptone medium, the naphthalenones appear first in the richer medium despite the fact that biomass proliferation is relatively unrestricted in that medium. Radiolabelled [1-14C]-acetate is taken up quickly by the fungus (k = 0.09 min-1) and is incorporated effectively into the naphthalenones.
萘并酮类化合物芦笋酮及其6 - O - 甲基醚是由微小曲霉在分批模式下，于葡萄糖 - 甘氨酸 - 盐培养基中振荡培养的营养生长阶段产生的。这些次生代谢产物在发育中的孢子菌丝开始相互接触时首次出现，即在培养发展的非常早期阶段。将产生萘并酮类化合物的菌丝体重新悬浮于新培养基中并不能抑制其产生。当微小曲霉在葡萄糖 - 甘氨酸 - 盐培养基和葡萄糖 - 麦芽 - 蛋白胨培养基上平行生长时，尽管在较丰富的培养基中生物量增殖相对不受限制，但萘并酮类化合物首先在该培养基中出现。放射性标记的[1 - 14C] - 乙酸盐被真菌快速吸收（k = 0.09 min-1）并有效地掺入到萘并酮类化合物中。
