在伯基特淋巴瘤和鼻咽癌组织中检测到爱泼斯坦-巴尔病毒的DNA。
DNA of Epstein-Barr virus detected in tissue of Burkitt's lymphoma and nasopharyngeal carcinoma.
作者信息
Nonoyama M, Huang C H, Pagano J S, Klein G, Singh S
出版信息
Proc Natl Acad Sci U S A. 1973 Nov;70(11):3265-8. doi: 10.1073/pnas.70.11.3265.
Abstract
The association of Epstein-Barr virus (EBV) DNA with African tumors was examined by the method of hybridization with complementary RNA. 22 out of 23 biopsies of Burkitt's lymphoma and 18 out of 23 biopsies of nasopharyngeal carcinoma were found to contain EBV DNA. The number of EBV genome equivalents per cell ranged from four to 113. Five out of 24 other African tumors, two adenocarcinomas, and one each of melanoma, reticulum cell sarcoma, and carcinoma of the antrum, also contained EBV DNA.
摘要
采用与互补RNA杂交的方法检测了爱泼斯坦-巴尔病毒（EBV）DNA与非洲肿瘤的关联。在23例伯基特淋巴瘤活检样本中，有22例被发现含有EBV DNA；在23例鼻咽癌活检样本中，有18例含有EBV DNA。每个细胞中EBV基因组等效物的数量在4到113之间。在24例其他非洲肿瘤中，有5例也含有EBV DNA，其中包括2例腺癌，以及1例黑色素瘤、1例网状细胞肉瘤和1例胃窦癌。
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