Dogan Snjezana, Hedberg Matthew L, Ferris Robert L, Rath Tanya J, Assaad Adel M, Chiosea Simion I
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York.
Head Neck. 2014 Apr;36(4):511-6. doi: 10.1002/hed.23318. Epub 2013 Jun 18.
The significance of human papillomavirus (HPV) in nasopharyngeal carcinomas (NPCs) in a low-incidence population remains unknown.
Samples from 90 patients with NPC (years, 1957-2012) were analyzed for Epstein-Barr virus (EBV). Clinical data, EBV, HPV, and p16 status were correlated with overall survival (OS; 63 cases; years, 1981-2012).
Of 9 HPV-positive cases, 3 extended from extra-nasopharyngeal sites. Nasopharyngeal origin was confirmed in 6 cases. HPV-positive NPC had OS similar to EBV-positive NPC (85 vs 141 months; p > .05). The OS of patients with EBV/HPV-negative NPC was worse (34 months; p = .004). Nonkeratinizing histology was associated with better outcome than keratinizing (115 vs 25 months; p = .001). Over the last several decades, the proportion of keratinizing NPC decreased from 34.5% to 14.3% (p = .026).
The etiologic role of HPV in NPC is confirmed. The favorable prognostic significance of HPV positivity is similar to that of EBV positivity.
人乳头瘤病毒（HPV）在低发人群鼻咽癌（NPC）中的意义尚不清楚。
对90例NPC患者（年份，1957 - 2012年）的样本进行了爱泼斯坦 - 巴尔病毒（EBV）分析。临床数据、EBV、HPV和p16状态与总生存期（OS；63例；年份，1981 - 2012年）相关。
在9例HPV阳性病例中，3例起源于鼻咽外部位。6例确诊为鼻咽起源。HPV阳性的NPC患者的总生存期与EBV阳性的NPC患者相似（85个月对141个月；p > 0.05）。EBV/HPV阴性的NPC患者的总生存期较差（34个月；p = 0.004）。非角化组织学的预后优于角化组织学（115个月对25个月；p = 0.001）。在过去几十年中，角化性NPC的比例从34.5%降至14.3%（p = 0.026）。
HPV在NPC中的病因学作用得到证实。HPV阳性的良好预后意义与EBV阳性相似。
