λ噬菌体c3基因和大肠杆菌分解代谢物基因激活系统在λ噬菌体溶原化建立过程中的作用。
The roles of the lambda c3 gene and the Escherichia coli catabolite gene activation system in the establishment of lysogeny by bacteriophage lambda.
作者信息
Belfort M, Wulff D
出版信息
Proc Natl Acad Sci U S A. 1974 Mar;71(3):779-82. doi: 10.1073/pnas.71.3.779.
Abstract
Maximum lysogenization of E. coli by bacteriophage lambda requires both the lambdacIII gene function and the host catabolite gene activation system mediated by adenosine 3':5'-cyclic monophosphate. Whereas considerable lysogenization occurs in the presence of either system alone, lysogenization is absolutely prevented in the absence of both systems. Neither system is, however, required for efficient lysogenization when the host bears an hfl(-) mutation. It is argued that the normal function of these two systems is to negate the antagonistic effect of the Hfl(+) protein upon lysogenization. It is further argued that both the lambdacIII gene function and the Hfl(+) protein do not directly affect the host catabolite gene activation system.
摘要
噬菌体λ对大肠杆菌的最大溶原化需要λcIII基因功能和由3':5'-环磷酸腺苷介导的宿主分解代谢物基因激活系统。虽然单独存在任何一个系统时都会发生相当程度的溶原化，但在两个系统都不存在的情况下，溶原化被完全阻止。然而，当宿主带有hfl(-)突变时，高效溶原化不需要这两个系统中的任何一个。有人认为这两个系统的正常功能是消除Hfl(+)蛋白对溶原化的拮抗作用。进一步有人认为，λcIII基因功能和Hfl(+)蛋白都不会直接影响宿主分解代谢物基因激活系统。
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