印防己毒素对大鼠黑质中γ-氨基丁酸抑制反应和突触抑制的拮抗作用。
Picrotoxin antagonism of gamma-aminobutyric acid inhibitory responses and synaptic inhibition in the rat substantia nigra.
作者信息
Crossman A R, Walker R J, Woodruff G N
出版信息
Br J Pharmacol. 1973 Dec;49(4):696-8. doi: 10.1111/j.1476-5381.1973.tb08546.x.
Abstract
Neurones in the substantia nigra of the rat, anaesthetized with urethane, are inhibited both by electrical stimulation of the ipsilateral caudate nucleus and by iontophoretically applied gamma-aminobutyric acid (GABA). Iontophoretically applied picrotoxin reversibly blocks both of these inhibitory responses. These results are consistent with the hypothesis that GABA is the transmitter released by the inhibitory striato-nigral pathway.
摘要
用氨基甲酸乙酯麻醉的大鼠，其黑质中的神经元受到同侧尾状核的电刺激以及离子导入施加的γ-氨基丁酸（GABA）的抑制。离子导入施加的苦味毒可可逆地阻断这两种抑制反应。这些结果与GABA是抑制性纹状体-黑质通路释放的递质这一假说一致。
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