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脂质和脂蛋白的家族相似性分析。

Analysis of family resemblance for lipids and lipoproteins.

作者信息

Iselius L

出版信息

Clin Genet. 1979 Apr;15(4):300-6. doi: 10.1111/j.1399-0004.1979.tb01738.x.

DOI:10.1111/j.1399-0004.1979.tb01738.x
PMID:436327
Abstract

A path analysis of published reports on family resemblance reveals an important role for genetic factors in all lipids and lipoproteins, with no evidence of a discrepancy between twins and other relatives (which might be due to dominance or epistasis) nor between studies which used environmental indices and those which did not. Family environment within population is less important and is significantly greater for twins than for other relatives.

摘要

对已发表的关于家族相似性报告的路径分析表明,遗传因素在所有脂质和脂蛋白中都起着重要作用,没有证据表明双胞胎与其他亲属之间存在差异(这可能是由于显性或上位性),也没有证据表明使用环境指标的研究与未使用环境指标的研究之间存在差异。群体中的家庭环境不太重要,双胞胎的家庭环境影响显著大于其他亲属。

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1
Analysis of family resemblance for lipids and lipoproteins.脂质和脂蛋白的家族相似性分析。
Clin Genet. 1979 Apr;15(4):300-6. doi: 10.1111/j.1399-0004.1979.tb01738.x.
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引用本文的文献

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Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: the Family Blood Pressure Program.纳入基因-年龄相互作用的连锁分析确定了七个新的脂质基因座:家族血压项目。
Atherosclerosis. 2014 Jul;235(1):84-93. doi: 10.1016/j.atherosclerosis.2014.04.008. Epub 2014 Apr 26.
2
The age dependency of gene expression for plasma lipids, lipoproteins, and apolipoproteins.血浆脂质、脂蛋白和载脂蛋白基因表达的年龄依赖性。
Am J Hum Genet. 1997 Mar;60(3):638-50.
3
Detection of genetic heterogeneity among pedigrees through complex segregation analysis: an application to hypercholesterolemia.
通过复杂分离分析检测家系间的遗传异质性:在高胆固醇血症中的应用。
Am J Hum Genet. 1984 Jan;36(1):197-211.
4
Resolution of genetic and cultural inheritance in twin families by path analysis: application to HDL-cholesterol.通过路径分析解析双胞胎家庭中的遗传和文化遗传:应用于高密度脂蛋白胆固醇
Am J Hum Genet. 1985 Sep;37(5):998-1014.
5
Segregation analysis of low levels of high-density lipoprotein cholesterol in the collaborative Lipid Research Clinics Program Family Study.脂质研究临床协作项目家族研究中高密度脂蛋白胆固醇低水平的分离分析。
Am J Hum Genet. 1987 Jun;40(6):489-502.
6
Pedigree analysis of HDL cholesterol concentration in baboons on two diets.两种饮食条件下巴基狒狒高密度脂蛋白胆固醇浓度的系谱分析
Am J Hum Genet. 1988 Oct;43(4):401-13.