异丙肌苷对志愿者鼻病毒感染抗病毒作用的试验。
Trial of the antiviral action of isoprinosine against rhinovirus infection of volunteers.
作者信息
Soto A J, Hall T S, Reed S E
出版信息
Antimicrob Agents Chemother. 1973 Mar;3(3):332-4. doi: 10.1128/AAC.3.3.332.
Abstract
Isoprinosine (NPT-10381) was given orally to a group of 22 volunteers at a daily dose of 6 g for 7 days; a control group of 23 volunteers received placebo. Volunteers were inoculated intranasally with both rhinovirus type 9 and rhinovirus type 31, and the clinical picture, extent of virus shedding, and serological responses were assessed. There was no evidence that the compound had useful antiviral activity under the conditions of this trial.
摘要
将异丙肌苷（NPT - 10381）以每日6克的剂量口服给予一组22名志愿者，持续7天；另一组23名志愿者作为对照组，接受安慰剂。志愿者通过鼻腔接种9型鼻病毒和31型鼻病毒，然后评估其临床症状、病毒排出程度和血清学反应。在该试验条件下，没有证据表明该化合物具有有效的抗病毒活性。
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