异丙肌苷对志愿者感染A(H3N2) - 香港流感病毒的挑战的影响。
Effect of isoprinosine against challenge with A(H3N2)-Hong Kong influenza virus in volunteers.
作者信息
Longley S, Dunning R L, Waldman R H
出版信息
Antimicrob Agents Chemother. 1973 Apr;3(4):506-9. doi: 10.1128/AAC.3.4.506.
Abstract
Volunteers were challenged with A(H(3)N(2))/Hong Kong/8/68 influenza virus while being given prophylaxis with either isoprinosine or placebo in a double-blind experiment. Isoprinosine, which had demonstrable antiviral activity in animal models, did not appear to protect humans from clinical influenza. The only beneficial effect of the drug observed was a slight, but significant, reduction in virus shedding.
摘要
在一项双盲实验中，志愿者在接受异搏定或安慰剂预防的同时，受到A(H(3)N(2))/香港/8/68流感病毒的攻击。异搏定在动物模型中具有明显的抗病毒活性，但似乎并不能保护人类免受临床流感的侵袭。观察到的该药物唯一有益效果是病毒排出量略有但显著减少。
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The antiviral activity of isoprinosine.异丙肌苷的抗病毒活性。
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