一种真菌来源的多核苷酸干扰素诱导剂对人类实验性鼻病毒感染的影响。
Effect of a polynucleotide interferon inducer of fungal origin on experimental rhinovirus infection in humans.
作者信息
Aoki F Y, Reed S E, Craig J W, Tyrrell D A, Lees L J
出版信息
J Infect Dis. 1978 Jan;137(1):82-6. doi: 10.1093/infdis/137.1.82.
A double-stranded RNA of fungal origin (BRL 5907) was given intranasally to volunteers. Apart from mild local irritancy of the higher dosage, the compound was well tolerated. A double-blind placebo-controlled trial of a three-day course (5 mg per day) of BRL 5907 against challenge with rhinovirus type 4 showed that treatment was associated with a delay in onset of symptoms and a reduction in shedding of virus, but the differences were not statistically significant. Low titers of interferon were found in nasal washings.
将源自真菌的双链RNA（BRL 5907）经鼻给予志愿者。除了较高剂量时会有轻微的局部刺激外，该化合物耐受性良好。一项针对BRL 5907进行的为期三天疗程（每天5毫克）、与4型鼻病毒激发试验对比的双盲安慰剂对照试验表明，治疗与症状出现延迟及病毒排出减少有关，但差异无统计学意义。在鼻腔灌洗液中发现了低滴度的干扰素。
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