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小鼠（小家鼠）中香豆素羟化酶活性的遗传变异。

Genetic variation in coumarin hydroxylase activity in the mouse (Mus musculus).

作者信息

Wood A W, Conney A H

出版信息

Science. 1974 Aug 16;185(4151):612-4. doi: 10.1126/science.185.4151.612.

DOI:10.1126/science.185.4151.612
PMID:4366489
Abstract

Basal and phenobarbital-induced rates of hepatic metabolism of coumarin to 7-hydroxycoumarin are markedly higher in DBA/2J mice than they are in the AKR/J, C57BL/6J, and C3H/HeJ strains. Intermediate coumarin hydroxylase activity in F(1) hybrids of mating between DBA/2J and the other three strains indicates an additive mode of inheritance.

摘要

在DBA/2J小鼠中，香豆素向7-羟基香豆素的基础代谢率和苯巴比妥诱导的肝代谢率明显高于AKR/J、C57BL/6J和C3H/HeJ品系。DBA/2J与其他三个品系杂交产生的F(1)杂种中香豆素羟化酶活性处于中间水平，表明其遗传方式为加性遗传。

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