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Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 2. Tilorone and related bis-basic ethers of fluorenone, fluorenol, and fluorene.

作者信息

Andrews E R, Fleming R W, Grisar J M, Kihm J C, Wenstrup D L, Mayer G D

出版信息

J Med Chem. 1974 Aug;17(8):882-6. doi: 10.1021/jm00254a020.

DOI:10.1021/jm00254a020
PMID:4367593
Abstract
摘要

相似文献

1
Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 2. Tilorone and related bis-basic ethers of fluorenone, fluorenol, and fluorene.双碱性取代的多环芳香族化合物。一类新型抗病毒剂。2. 替洛隆及芴酮、芴醇和芴的相关双碱性醚。
J Med Chem. 1974 Aug;17(8):882-6. doi: 10.1021/jm00254a020.
2
Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 1. Bisalkamine esters of fluorenone-, fluorenol-, and fluorenedicarboxylic acids.
J Med Chem. 1973 Mar;16(3):240-5. doi: 10.1021/jm00261a016.
3
Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 3. 2,7-Bis(aminoacyl)fluorenes and -fluorenones.双碱性取代的多环芳香化合物。一类新型抗病毒剂。3. 2,7-双（氨酰基）芴和芴酮
J Med Chem. 1974 Aug;17(8):886-9. doi: 10.1021/jm00254a021.
4
Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 1,2 6. Bis-basic-substituted fluoranthenes.双碱取代的多环芳香化合物。一类新型抗病毒剂。1,2,6 - 双碱取代荧蒽。
J Med Chem. 1974 Nov;17(11):1150-6. doi: 10.1021/jm00257a005.
5
Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 4. Bis-basic sulfonamides of anthraquinone.双碱性取代的多环芳香族化合物。一类新型抗病毒剂。4. 蒽醌的双碱性磺酰胺。
J Med Chem. 1974 Aug;17(8):890-3. doi: 10.1021/jm00254a022.
6
Interferon inducers in therapy of infection with encephalomyocarditis virus in mice. I. Effect of single doses of polyriboinosinic-polyribocytidylic acid and tilorone hydrochloride on viral pathogenesis.干扰素诱导剂对小鼠脑心肌炎病毒感染的治疗作用。I. 单剂量聚肌苷酸-聚胞苷酸和盐酸泰洛龙对病毒发病机制的影响。
J Infect Dis. 1974 Nov;130(5):470-80. doi: 10.1093/infdis/130.5.470.
7
Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 7. Bisalkamine esters of 9-oxoxanthene-2,7-dicarboxylic acid, 3,6-bis-basic ethers of xanthen-9-one, and 2,7-bis(aminoacyl)xanthen-9-ones-xanthenes, and -thioxanthenes.
J Med Chem. 1976 Sep;19(9):1142-8. doi: 10.1021/jm00231a012.
8
Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 8. Bis-basic derivatives of carbazole, dibenzofuran, and dibenzothiophene.
J Med Chem. 1977 Mar;20(3):364-71. doi: 10.1021/jm00213a011.
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Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 5. Bis-basic ethers of anthraquinone and bisalkamine esters of anthraquinonedicarboxylic acids.
J Med Chem. 1974 Sep;17(9):965-8. doi: 10.1021/jm00255a011.
10
Tilorone hydrochloride: an orally active antiviral agent.盐酸替洛隆：一种口服活性抗病毒剂。
Science. 1970 Sep 18;169(3951):1213-4. doi: 10.1126/science.169.3951.1213.

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DFT and QTAIM analysis of fluorenol and fluorenone in molecular nanoelectronics.分子纳米电子学中芴醇和芴酮的密度泛函理论（DFT）与量子拓扑原子分子理论（QTAIM）分析
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2
An Effective Synthesis Method for Tilorone Dihydrochloride with Obvious IFN-α Inducing Activity.一种具有明显干扰素-α诱导活性的盐酸替洛隆有效合成方法。
Molecules. 2015 Dec 2;20(12):21458-63. doi: 10.3390/molecules201219781.
3
Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
区域选择性合成 6-取代-2-氨基-5-溴-4(3H)-嘧啶酮及其抗病毒活性评价。
Eur J Med Chem. 2013 Sep;67:428-33. doi: 10.1016/j.ejmech.2013.06.036. Epub 2013 Jul 5.
4
Tilorone-induced lysosomal lesions: the bisbasic character of the drug is essential for its high potency to cause storage of sulphated glycosaminoglycans.泰洛龙诱导的溶酶体损伤：药物的双碱性特征对其导致硫酸化糖胺聚糖蓄积的高效力至关重要。
Biochem J. 1996 Apr 15;315 ( Pt 2)(Pt 2):369-75. doi: 10.1042/bj3150369.
5
Comparison of the ability of small molecular interferon inducers: tilorone and acridine drugs.
Arch Virol. 1975;48(4):375-84. doi: 10.1007/BF01317436.
6
Antiviral and interferon-inducing properties of 1,5-diamino anthraquinones.1,5-二氨基蒽醌的抗病毒及诱导干扰素特性
Antimicrob Agents Chemother. 1979 Jan;15(1):111-8. doi: 10.1128/AAC.15.1.111.
7
Stimulation of murine interferon by a substituted pyrimidine.一种取代嘧啶对小鼠干扰素的刺激作用。
Antimicrob Agents Chemother. 1976 Mar;9(3):433-9. doi: 10.1128/AAC.9.3.433.
8
Inhibition of herpesvirus deoxyribonucleic acid and protein synthesis by tilorone hydrochloride.盐酸替洛隆对疱疹病毒脱氧核糖核酸和蛋白质合成的抑制作用
Antimicrob Agents Chemother. 1976 Jan;9(1):189-95. doi: 10.1128/AAC.9.1.189.