双碱性取代的多环芳香族化合物。一类新型抗病毒剂。2. 替洛隆及芴酮、芴醇和芴的相关双碱性醚。 - Suppr

Suppr

超能文献

Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 2. Tilorone and related bis-basic ethers of fluorenone, fluorenol, and fluorene.

作者信息

Andrews E R, Fleming R W, Grisar J M, Kihm J C, Wenstrup D L, Mayer G D

出版信息

J Med Chem. 1974 Aug;17(8):882-6. doi: 10.1021/jm00254a020.

DOI:10.1021/jm00254a020

PMID:4367593

Abstract

摘要

相似文献

Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 2. Tilorone and related bis-basic ethers of fluorenone, fluorenol, and fluorene.双碱性取代的多环芳香族化合物。一类新型抗病毒剂。2. 替洛隆及芴酮、芴醇和芴的相关双碱性醚。

J Med Chem. 1974 Aug;17(8):882-6. doi: 10.1021/jm00254a020.

Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 1. Bisalkamine esters of fluorenone-, fluorenol-, and fluorenedicarboxylic acids.

J Med Chem. 1973 Mar;16(3):240-5. doi: 10.1021/jm00261a016.

Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 3. 2,7-Bis(aminoacyl)fluorenes and -fluorenones.双碱性取代的多环芳香化合物。一类新型抗病毒剂。3. 2,7-双（氨酰基）芴和芴酮

J Med Chem. 1974 Aug;17(8):886-9. doi: 10.1021/jm00254a021.

Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 1,2 6. Bis-basic-substituted fluoranthenes.双碱取代的多环芳香化合物。一类新型抗病毒剂。1,2,6 - 双碱取代荧蒽。

J Med Chem. 1974 Nov;17(11):1150-6. doi: 10.1021/jm00257a005.

Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 4. Bis-basic sulfonamides of anthraquinone.双碱性取代的多环芳香族化合物。一类新型抗病毒剂。4. 蒽醌的双碱性磺酰胺。

J Med Chem. 1974 Aug;17(8):890-3. doi: 10.1021/jm00254a022.

Interferon inducers in therapy of infection with encephalomyocarditis virus in mice. I. Effect of single doses of polyriboinosinic-polyribocytidylic acid and tilorone hydrochloride on viral pathogenesis.干扰素诱导剂对小鼠脑心肌炎病毒感染的治疗作用。I. 单剂量聚肌苷酸-聚胞苷酸和盐酸泰洛龙对病毒发病机制的影响。

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Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 7. Bisalkamine esters of 9-oxoxanthene-2,7-dicarboxylic acid, 3,6-bis-basic ethers of xanthen-9-one, and 2,7-bis(aminoacyl)xanthen-9-ones-xanthenes, and -thioxanthenes.

J Med Chem. 1976 Sep;19(9):1142-8. doi: 10.1021/jm00231a012.

Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 8. Bis-basic derivatives of carbazole, dibenzofuran, and dibenzothiophene.

J Med Chem. 1977 Mar;20(3):364-71. doi: 10.1021/jm00213a011.

Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 5. Bis-basic ethers of anthraquinone and bisalkamine esters of anthraquinonedicarboxylic acids.

J Med Chem. 1974 Sep;17(9):965-8. doi: 10.1021/jm00255a011.

Tilorone hydrochloride: an orally active antiviral agent.盐酸替洛隆：一种口服活性抗病毒剂。

Science. 1970 Sep 18;169(3951):1213-4. doi: 10.1126/science.169.3951.1213.

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Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.区域选择性合成 6-取代-2-氨基-5-溴-4(3H)-嘧啶酮及其抗病毒活性评价。

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Tilorone-induced lysosomal lesions: the bisbasic character of the drug is essential for its high potency to cause storage of sulphated glycosaminoglycans.泰洛龙诱导的溶酶体损伤：药物的双碱性特征对其导致硫酸化糖胺聚糖蓄积的高效力至关重要。

Biochem J. 1996 Apr 15;315 ( Pt 2)(Pt 2):369-75. doi: 10.1042/bj3150369.

Comparison of the ability of small molecular interferon inducers: tilorone and acridine drugs.

Arch Virol. 1975;48(4):375-84. doi: 10.1007/BF01317436.

Antiviral and interferon-inducing properties of 1,5-diamino anthraquinones.1,5-二氨基蒽醌的抗病毒及诱导干扰素特性

Antimicrob Agents Chemother. 1979 Jan;15(1):111-8. doi: 10.1128/AAC.15.1.111.

Stimulation of murine interferon by a substituted pyrimidine.一种取代嘧啶对小鼠干扰素的刺激作用。

Antimicrob Agents Chemother. 1976 Mar;9(3):433-9. doi: 10.1128/AAC.9.3.433.

Inhibition of herpesvirus deoxyribonucleic acid and protein synthesis by tilorone hydrochloride.盐酸替洛隆对疱疹病毒脱氧核糖核酸和蛋白质合成的抑制作用

Antimicrob Agents Chemother. 1976 Jan;9(1):189-95. doi: 10.1128/AAC.9.1.189.

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