锌离子存在下产生的大微小核糖核酸病毒多肽的特性分析。
Characterization of the large picornaviral polypeptides produced in the presence of zinc ion.
作者信息
Butterworth B E, Korant B D
出版信息
J Virol. 1974 Aug;14(2):282-91. doi: 10.1128/JVI.14.2.282-291.1974.
Abstract
Zinc ion inhibits the posttranslational cleavages of human rhinovirus-1A, encephalomyocarditis virus, and poliovirus polypeptides. Each virus displayed a different susceptibility to zinc. However, in each case the cleavages of the capsid precursor and the cleavages analogous to the C --> D --> E conversion in encephalomyocarditis virus were most sensitive to zinc. Higher concentrations of zinc resulted in the buildup of even larger precursor polypeptides of a size between 106,000 and 214,000 daltons. The sizes of these polypeptides and the relative position of their gene loci on the viral RNA were determined. These data were used to place these polypeptides in the over-all scheme of viral protein processing.
摘要
锌离子可抑制人鼻病毒-1A、脑心肌炎病毒和脊髓灰质炎病毒多肽的翻译后切割。每种病毒对锌的敏感性不同。然而，在每种情况下，衣壳前体的切割以及类似于脑心肌炎病毒中C→D→E转化的切割对锌最为敏感。较高浓度的锌会导致大小在106,000至214,000道尔顿之间的更大前体多肽的积累。测定了这些多肽的大小及其基因座在病毒RNA上的相对位置。这些数据被用于将这些多肽置于病毒蛋白质加工的整体流程中。
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Picornaviral gene order: comparison of a rhinovirus with a cardiovirus.小核糖核酸病毒基因顺序：一种鼻病毒与一种心病毒的比较。
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Kinetics of synthesis and cleavage of encephalomyocarditis virus-specific proteins.
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