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Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.

作者信息

Goldstein J L, Brown M S

出版信息

J Biol Chem. 1974 Aug 25;249(16):5153-62.

PMID:4368448
Abstract
摘要

相似文献

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Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.培养的人成纤维细胞对低密度脂蛋白的结合与降解。正常受试者与纯合子家族性高胆固醇血症患者细胞的比较。
J Biol Chem. 1974 Aug 25;249(16):5153-62.
2
Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity.家族性高胆固醇血症：脂蛋白与培养的成纤维细胞结合缺陷，与3-羟基-3-甲基戊二酰辅酶A还原酶活性调节受损有关。
Proc Natl Acad Sci U S A. 1974 Mar;71(3):788-92. doi: 10.1073/pnas.71.3.788.
3
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.培养的人成纤维细胞中3-羟基-3-甲基戊二酰辅酶A还原酶活性的调节。正常受试者与纯合子家族性高胆固醇血症患者细胞的比较。
J Biol Chem. 1974 Feb 10;249(3):789-96.
4
Hyperlipidemia in coronary heart disease: a biochemical genetic approach.
J Lab Clin Med. 1975 Jan;85(1):15-25.
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Genetic heterogeneity in familial hypercholesterolemia: evidence for two different mutations affecting functions of low-density lipoprotein receptor.家族性高胆固醇血症中的遗传异质性：影响低密度脂蛋白受体功能的两种不同突变的证据。
Proc Natl Acad Sci U S A. 1975 Mar;72(3):1092-6. doi: 10.1073/pnas.72.3.1092.
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Use of mutant fibroblasts in the analysis of the regulation of cholesterol metabolism in human cells.突变成纤维细胞在人类细胞胆固醇代谢调节分析中的应用。
J Cell Physiol. 1975 Apr;85(2 Pt 2 Suppl 1):425-36. doi: 10.1002/jcp.1040850409.
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Localization of low density lipoprotein receptors on plasma membrane of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote.正常人成纤维细胞质膜上低密度脂蛋白受体的定位及其在家族性高胆固醇血症纯合子细胞中的缺失。
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2434-8. doi: 10.1073/pnas.73.7.2434.
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Expression of the familial hypercholesterolemia gene in heterozygotes: model for a dominant disorder in man.
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Enhanced degradation of trypsin-treated low density lipoprotein by fibroblasts from a patient with homozygous familial hypercholesterolemia.纯合子家族性高胆固醇血症患者的成纤维细胞对经胰蛋白酶处理的低密度脂蛋白的降解增强。
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Expression of the familial hypercholesterolemia gene in heterozygotes: mechanism for a dominant disorder in man.家族性高胆固醇血症基因在杂合子中的表达：人类显性疾病的机制。
Science. 1974 Jul 5;185(4145):61-3. doi: 10.1126/science.185.4145.61.

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