因透明膜病接受机械通气的婴儿预后改善。
Improved prognosis of infants mechanically ventilated for hyaline membrane disease.
作者信息
Reynolds E O, Taghizadeh A
出版信息
Arch Dis Child. 1974 Jul;49(7):505-15. doi: 10.1136/adc.49.7.505.
Abstract
The results of mechanical ventilation for severe hyaline membrane disease (HMD), and the changes in technique which took place, during the 6-year period 1967-72 are described. A pilot study of the effect of hydrocortisone among the most severely affected infants showed no benefit. After the introduction at the beginning of 1970 of a regimen for ventilating the infants at low peak airway pressures, slow respiratory frequencies, and high inspiration: expiration ratios, there was a sudden increase in survival rate which was largely accounted for by a reduction in the incidence of bronchopulmonary dysplasia. Evidence is presented that in infants with HMD mechanical factors are more important than oxygen toxicity in the pathogenesis of this condition.
摘要
本文描述了1967年至1972年这6年间，对重症透明膜病（HMD）进行机械通气的结果以及技术上发生的变化。对病情最严重的婴儿使用氢化可的松的初步研究未显示出益处。1970年初开始采用一种通气方案，即对婴儿采用低气道峰压、慢呼吸频率和高吸气：呼气比进行通气，此后存活率突然上升，这主要是由于支气管肺发育不良的发生率降低。有证据表明，在患有HMD的婴儿中，机械因素在该病的发病机制中比氧中毒更重要。
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