Wong Y C, Beardsmore C S, Silverman M
Arch Dis Child. 1982 Jun;57(6):418-24. doi: 10.1136/adc.57.6.418.
Twenty infants, mechanically ventilated in the neonatal period for respiratory distress syndrome, were compared with 15 healthy controls, matched for birthweight(less than 1501 g) but greater in mean gestational age. Clinical features and lung mechanics (by whole body plethysmography) were recorded at 6-monthly intervals until about one year. THe neonatal course of the mechanically ventilated infants was commonly complicated by tracheobronchial hypersecretion and the later course by a fairly high incidence of lower respiratory tract illness. In this group, thoracic gas volume, dynamic compliance, pulmonary and airways conductance were all abnormal during the middle 4 months of the first year and reverted towards normal towards the end of the first year. The control group had normal lung mechanics. Early lung function tests were of limited value in predicting later lower respiratory tract illness, which was more common in boys, after neonatal mechanical ventilation for longer than 24 hours or raised ambient oxygen for longer than 5 days. There were few predictive physical signs. In this group of very low birthweight infants, respiratory distress syndrome of sufficient severity to require mechanical ventilation led to significant physiological and clinical disturbances of lung function which lasted into the second 6 months of life and which were particularly severe in those who had recurrent lower respiratory tract illness.
20名因呼吸窘迫综合征在新生儿期接受机械通气的婴儿与15名健康对照者进行了比较，两组出生体重匹配（小于1501克），但平均胎龄更大。每隔6个月记录临床特征和肺力学指标（通过全身体积描记法），直至约1岁。接受机械通气的婴儿新生儿期病程常见气管支气管分泌过多并发症，后期下呼吸道疾病发病率相当高。在这组婴儿中，第一年中间4个月时胸廓气体容积、动态顺应性、肺和气道传导率均异常，接近第一年末时恢复正常。对照组肺力学指标正常。早期肺功能测试在预测后期下呼吸道疾病方面价值有限，下呼吸道疾病在男孩中更常见，发生于新生儿机械通气超过24小时或环境氧浓度升高超过5天之后。几乎没有预测性体征。在这组极低出生体重婴儿中，严重到需要机械通气的呼吸窘迫综合征导致了显著的肺功能生理和临床紊乱，这种紊乱持续到生命的第二个6个月，在反复发生下呼吸道疾病的婴儿中尤为严重。
