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“诺卡氏菌”亚基在仓鼠体内诱导产生的干扰素:狂犬病预防试验(作者译)

[Interferon induced in the hamster by subunits of "Nocardia": essay of protection against rabies (author's transl)].

作者信息

Barot-Ciorbaru R, Yokota Y, Petit J F, Chedid L, Atanasiu P

出版信息

Ann Microbiol (Paris). 1979 Aug-Sep;130B(2):263-9.

PMID:43690
Abstract

Lipid-free cells of Nocardia opaca and a cell extract (NWSM) are interferon inducers in syrian hamsters: peak interferon appears 2 h after injection as compared to 8 h in the case of interferon induced by inactivated NDV virus. The interferon induced by Nocardia product is inactivated by a treatment for 30 min at 56 degrees C or 24 h at pH 2: NDV-induced interferon is more stable under these conditions. Hamsters inoculated with NWSM before and after infection with rabies virus are partially protected: their survival time is slightly increased.

摘要

暗色诺卡氏菌的无脂细胞和一种细胞提取物(NWSM)是叙利亚仓鼠体内的干扰素诱导剂:注射后2小时出现干扰素峰值,而灭活的新城疫病毒诱导的干扰素则在8小时出现峰值。诺卡氏菌产物诱导的干扰素在56℃处理30分钟或在pH2条件下处理24小时后会失活:在这些条件下,新城疫病毒诱导的干扰素更稳定。在感染狂犬病病毒之前和之后接种NWSM的仓鼠受到部分保护:它们的存活时间略有延长。

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