诺卡氏菌提取物诱导小鼠体内干扰素的合成
Induction of interferon synthesis in mice by fractions from Nocardia.
作者信息
Barot-Ciorbaru R, Wietzerbin J, Petit J F, Chedid L, Falcoff E, Lederer E
出版信息
Infect Immun. 1978 Feb;19(2):353-6. doi: 10.1128/iai.19.2.353-356.1978.
Abstract
Three fractions of Nocardia, Nocardia water-soluble mitogen (NWSM), Nocardia water-soluble mitogen pellet (NWSMP), and the cell wall peptidoglycan, which are mitogenic for B lymphocytes, were able to induce circulating interferon in mice, NWSMP and NWSM being the most active. The peak of interferon appeared about 2 h after injection. The interferon induced by NSWMP and NWSM was acid stable and antigenically related to viral interferon, as shown by neutralization with antibodies directed against Newcastle disease virus-induced interferon.
摘要
诺卡氏菌的三个组分，即诺卡氏菌水溶性促细胞分裂原（NWSM）、诺卡氏菌水溶性促细胞分裂原沉淀（NWSMP）以及对B淋巴细胞有促有丝分裂作用的细胞壁肽聚糖，能够在小鼠体内诱导循环干扰素，其中NWSMP和NWSM最为活跃。干扰素峰值在注射后约2小时出现。如用抗新城疫病毒诱导的干扰素抗体进行中和试验所示，NWSMP和NWSM诱导产生的干扰素对酸稳定，且在抗原性上与病毒干扰素相关。
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Purification of mouse interferon by affinity chromatography on anti-interferon globulin-sepharose.通过抗干扰素球蛋白-琼脂糖亲和层析法纯化小鼠干扰素。
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8
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J Immunol. 1976 Nov;117(5 Pt 1):1434-9.
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