乙醇运动效应中涉及的去甲肾上腺素能过程。

Noradrenergic processes involved in the locomotor effects of ethanol.

作者信息

Mason S T, Corcoran M E, Fibiger H C

出版信息

Eur J Pharmacol. 1979 Mar 15;54(4):383-7. doi: 10.1016/0014-2999(79)90068-2.

Abstract

Male albino Wistar rats were depleted of forebrain noradrenaline by intracerebral injection of 4 microgram of 6-hydroxydopamine into the noradrenaline bundles in the mesencephalon. The locomotor response was examined in response to intraperitoneal injection of ethanol. The locomotor stimulation by 0.1 g/kg ethanol was not altered by the lesion, whereas the sedation found in response to 1 g/kg in controls failed to occur in the lesioned rats and instead a stimulation was seen.

摘要

通过向雄性白化Wistar大鼠中脑的去甲肾上腺素束内脑室内注射4微克6-羟基多巴胺来耗尽其前脑去甲肾上腺素。检测腹腔注射乙醇后的运动反应。0.1 g/kg乙醇引起的运动刺激不受损伤的影响，而对照组中1 g/kg乙醇引起的镇静在损伤大鼠中未出现，反而出现了刺激作用。