大鼠体内去甲肾上腺素与乙醇的摄入量

Noradrenaline and ethanol intake in the rat.

作者信息

Mason S T, Corcoran M E, Fibiger H C

出版信息

Neurosci Lett. 1979 Apr;12(1):137-42. doi: 10.1016/0304-3940(79)91494-0.

Abstract

Intracerebral injection of 4 microgram of the neurotoxin 6-hydroxydopamine (6-OHDA) was used to deplete forebrain noradrenaline (NA) in rats to less than 5% of control values without affecting brain dopamine (DA) and the oral consumption of ethanol examined. Control rats showed a progressive increase in their intake of a 15% ethanol solution and after 15 days were consuming large quantities. This increase did not occur in NA depleted rats, which after 15 days had consumed no more than a few millilitres of the solution in total. The results are discussed in terms of a central noradrenergic basis of ethanol reward.

摘要

向大鼠脑内注射4微克神经毒素6-羟基多巴胺（6-OHDA），以将其前脑去甲肾上腺素（NA）耗竭至对照值的5%以下，同时不影响脑内多巴胺（DA），并检测乙醇的口服摄入量。对照大鼠对15%乙醇溶液的摄入量逐渐增加，15天后摄入量很大。NA耗竭的大鼠未出现这种增加，15天后它们总共摄入的溶液不超过几毫升。从乙醇奖赏的中枢去甲肾上腺素能基础方面对结果进行了讨论。