Corcoran M E, Lewis J, Fibiger H C
Behav Brain Res. 1983 Apr;8(1):1-21. doi: 10.1016/0166-4328(83)90168-7.
The effects of 6-hydroxydopamine-induced depletion of forebrain noradrenaline (NA) on oral intake of ethanol were studied in male Wistar rats. Prior depletion of NA produced a smaller and significantly less variable intake of a concentrated solution of ethanol than that of control rats, and this effect was not accompanied by hyperreactivity to aversive solutions of quinine. NA-depleted rats also displayed rejection 'thresholds' for ethanol solutions that were significantly lower than those of controls. Depletion of forebrain NA did not, however, affect the punishing effects of ethanol injections measured in the conditioned taste aversion paradigm. In contrast to these effects of NA depletion on initiation of ethanol intake, depletion of forebrain NA after a preference for ethanol had been established failed to affect subsequent intake of ethanol. These results suggest that forebrain NA is involved in the initiation of ethanol intake by naive rats but not in the maintenance of established patterns of intake by experienced rats. Possible mechanisms for this differential involvement of NA are discussed.
在雄性Wistar大鼠中研究了6-羟基多巴胺诱导的前脑去甲肾上腺素（NA）耗竭对乙醇口服摄入量的影响。与对照大鼠相比，预先耗竭NA会使浓缩乙醇溶液的摄入量更小且变异性显著更低，并且这种效应并未伴随着对奎宁厌恶溶液的高反应性。NA耗竭的大鼠对乙醇溶液的拒绝“阈值”也明显低于对照组。然而，前脑NA的耗竭并未影响在条件性味觉厌恶范式中测量的乙醇注射的惩罚作用。与NA耗竭对乙醇摄入起始的这些影响相反，在已建立对乙醇的偏好后前脑NA的耗竭未能影响随后的乙醇摄入量。这些结果表明，前脑NA参与了未接触过乙醇的大鼠的乙醇摄入起始，但不参与有饮酒经验大鼠已建立的饮酒模式的维持。文中讨论了NA这种不同参与情况的可能机制。
