Ioachim N J, Delaney W E, Madrazo A
Cancer. 1974 Sep;34(3):586-96. doi: 10.1002/1097-0142(197409)34:3<586::aid-cncr2820340316>3.0.co;2-q.
The villous component of nine colonic polyps (three pure villous adenoma and six mixed adenomatous and villous adenomas) was studied by light and electron microscopy. Normal colonic mucosa was used for control. The predominant cell was an undifferentiated epithelial cell resembling those of the base of the crypts of normal colonic mucosa. A minority of these cells differentiated toward goblet cells and absorptive cells. Interdigitations of the plasma membrane with enlarged intercellular spaces were frequently observed, possibly related to the loss of water and electrolytes in some of these tumors, suggesting an analogy to renal tubular plasma membrane changes in kalliopenic nephropathy. Numerous membrane-bound, inter and intracellular "inclusion bodies" representing degenerated lymphocytes and epithelial cell organelles were commonly found. Viral inclusions were not detected in this material. The possibility that the inclusion bodies observed in villous adenoma may represent lysosome-modified vesicles, secondary to absorption of protein and surface mucosubstances appears unlikely.
对九个结肠息肉（三个纯绒毛状腺瘤和六个混合性腺瘤性及绒毛状腺瘤）的绒毛成分进行了光镜和电镜研究。以正常结肠黏膜作为对照。主要细胞是未分化的上皮细胞，类似于正常结肠黏膜隐窝底部的细胞。这些细胞中的少数向杯状细胞和吸收细胞分化。经常观察到质膜的指状突伴有细胞间隙增宽，这可能与其中一些肿瘤中的水和电解质丢失有关，提示类似于低钾性肾病中肾小管质膜的变化。通常可发现许多代表退化淋巴细胞和上皮细胞器的膜结合的细胞内和细胞间“包涵体”。在该材料中未检测到病毒包涵体。绒毛状腺瘤中观察到的包涵体可能代表溶酶体修饰的囊泡，继发于蛋白质和表面黏液物质的吸收，这种可能性似乎不大。
