Balázs M
Morphol Igazsagugyi Orv Sz. 1980 Jul;20(3):161-9.
Characteristic patterns of the villous adenoma of colon have been studied by electron microscope in 12 cases. In accordance with the data of other investigators it was revealed that dominating cells of the villous adenoma were undifferentiated epithelial cells which normally occurred in Liberkühn crypts. Immaturity of cells, alteration of nuclei and pathologic changes of the cell-membrane seem to indicate malignant transformation. It is supposed, the Leuchtenberger's inclusion bodies develop as a result of strangulation of cytoplasmic processes. In tumours inducing electrolyte loss atypical cells showing evidence of mucus secretion have been observed, nevertheless mucus secreted by these cells differed from that of goblet cells of the normal colon epithelium. Author believes, that atypical cells secrete mucus of abnormal composition and this fact may lie on the basis of electrolyte losing syndrome.
应用电子显微镜对12例结肠绒毛状腺瘤的特征性形态进行了研究。根据其他研究者的数据发现，绒毛状腺瘤的主要细胞是未分化的上皮细胞，这些细胞通常存在于利伯屈恩隐窝中。细胞的不成熟、细胞核的改变以及细胞膜的病理变化似乎表明发生了恶性转化。据推测，勒克滕伯格包涵体是由于细胞质突起被绞窄而形成的。在导致电解质丢失的肿瘤中，观察到了显示黏液分泌迹象的非典型细胞，然而这些细胞分泌的黏液与正常结肠上皮杯状细胞分泌的黏液不同。作者认为，非典型细胞分泌成分异常的黏液，这一事实可能是电解质丢失综合征的基础。
