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肟类药物透过血脑屏障的研究。脑胆碱酯酶复活的组织化学研究。

Penetration of oximes across the blood-brain barrier. A histochemical study of the cerebral cholinesterases reactivation.

作者信息

De la Manche I S, Vergé D E, Bouchaud C, Coq H, Sentenac-Roumanou H

出版信息

Experientia. 1979 Apr 15;35(4):531-2. doi: 10.1007/BF01922752.

DOI:10.1007/BF01922752
PMID:437048
Abstract

The comparison of the effects of 4 oximes upon the cerebral cholinesterases reactivation after intoxication with paraoxon shows that the best results are obtained with toxogonine and 1574 [(carbaldoxime-4 pyridinium)-1(methyl-1 imidazolium-3)-3 propane]. The reactivation power of this latter compound seems due to the ease with which it can pass through the blood-brain barrier.

摘要

对4种肟类化合物在对氧磷中毒后对脑胆碱酯酶复活作用的比较表明，氯磷定和1574[（卡巴肟-4-吡啶鎓）-1-（甲基-1-咪唑鎓-3）-3-丙烷]能取得最佳效果。后一种化合物的复活能力似乎归因于其易于透过血脑屏障。

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本文引用的文献

1
A histochemical method for localizing cholinesterase activity.一种用于定位胆碱酯酶活性的组织化学方法。
Proc Soc Exp Biol Med. 1949 Apr;70(4):617-22. doi: 10.3181/00379727-70-17013.
2
[COMPARATIVE STUDIES ON THE POSSIBILITY OF PENETRATION OF SOME ESTERASE-ACTIVATING OXIMES INTO THE CENTRAL NERVOUS SYSTEM].[某些酯酶激活肟类化合物穿透中枢神经系统可能性的比较研究]
Arzneimittelforschung. 1965 Feb;15:135-9.
3
The histochemical localization of cholinesterases in the central nervous system of the rat.大鼠中枢神经系统中胆碱酯酶的组织化学定位
J Comp Neurol. 1954 Feb;100(1):211-35. doi: 10.1002/cne.901000108.
4
The reactivation by pyridium aldoximes of phosphorylated acetylcholinesterase in the central nervous system.吡啶醛肟对中枢神经系统中磷酸化乙酰胆碱酯酶的复活作用。
Biochem Pharmacol. 1967 Mar;16(3):455-62. doi: 10.1016/0006-2952(67)90093-7.