肟类药物透过血脑屏障的研究。脑胆碱酯酶复活的组织化学研究。
Penetration of oximes across the blood-brain barrier. A histochemical study of the cerebral cholinesterases reactivation.
作者信息
De la Manche I S, Vergé D E, Bouchaud C, Coq H, Sentenac-Roumanou H
出版信息
Experientia. 1979 Apr 15;35(4):531-2. doi: 10.1007/BF01922752.
PMID:437048
Abstract
The comparison of the effects of 4 oximes upon the cerebral cholinesterases reactivation after intoxication with paraoxon shows that the best results are obtained with toxogonine and 1574 [(carbaldoxime-4 pyridinium)-1(methyl-1 imidazolium-3)-3 propane]. The reactivation power of this latter compound seems due to the ease with which it can pass through the blood-brain barrier.
摘要
对4种肟类化合物在对氧磷中毒后对脑胆碱酯酶复活作用的比较表明，氯磷定和1574[（卡巴肟-4-吡啶鎓）-1-（甲基-1-咪唑鎓-3）-3-丙烷]能取得最佳效果。后一种化合物的复活能力似乎归因于其易于透过血脑屏障。
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