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[大鼠在有机磷抑制剂作用后胆碱酯酶重新激活时的脑皮层电图及组织化学效应]

[Electrocorticograms and the histochemical effects in the rat accompanying the reactivation of cholinesterases after the effects of an organophosphorus inhibitor].

作者信息

de La Manche I, Desroches A M, Bouchaud C, Laget P

出版信息

C R Seances Acad Sci D. 1980 Sep 29;291(4):401-3.

PMID:6777059
Abstract

The administration of paraoxon, an organophosphate inhibitor of cholinesterases, elicits theta rhythms, fast rhythms and paroxystical alterations on the electrocorticogram of the Rat. The disappearance of these abnormalities of the cortical activity after administration of aromatic oximes seems to be in good correlation with the restoration of cerebral cholinesterase activity revealed by histochemical method.

摘要

给予对氧磷（一种胆碱酯酶的有机磷酸酯抑制剂）会在大鼠的脑电图上引发θ节律、快节律和阵发性改变。给予芳香肟后皮质活动这些异常的消失似乎与通过组织化学方法显示的脑胆碱酯酶活性的恢复密切相关。

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