促肾上腺皮质激素明胶注射液治疗急性视神经炎的试验
A trial of corticotrophin gelatin injection in acute optic neuritis.
作者信息
Bowden A N, Bowden P M, Friedmann A I, Perkin G D, Rose F C
出版信息
J Neurol Neurosurg Psychiatry. 1974 Aug;37(8):869-73. doi: 10.1136/jnnp.37.8.869.
Abstract
The effect of a 30 day course of corticotrophin gelatin injections on the natural history of acute unilateral optic neuritis in 27 patients is reported. A further 27 patients received inert injections in a double-blind control. Measurements were made on visual acuity, visual field, macular threshold, and colour vision, and the development of optic atrophy and other neurological episodes was recorded. No significant differences were found between treated and control groups at intervals up to two years from the start of the trial. The criteria for inclusion of patients are given and it is concluded that corticotrophin has no effect on the natural history of the condition as defined.
摘要
报告了27例患者接受为期30天的促肾上腺皮质激素明胶注射疗程对急性单侧视神经炎自然病程的影响。另外27例患者在双盲对照中接受惰性注射。对视力、视野、黄斑阈值和色觉进行了测量，并记录了视神经萎缩和其他神经事件的发生情况。从试验开始至两年期间，治疗组和对照组之间未发现显著差异。给出了患者纳入标准，并得出结论：促肾上腺皮质激素对所定义疾病的自然病程没有影响。
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