调控干扰素诱导抗病毒状态的人类基因的染色体定位。
Chromosomal localization of human genes governing the interferon-induced antiviral state.
作者信息
Chany C, Vignal M, Couillin P, Van Cong N, Boué J, Boué A
出版信息
Proc Natl Acad Sci U S A. 1975 Aug;72(8):3129-33. doi: 10.1073/pnas.72.8.3129.
Abstract
Interferon sensitivity of different normal and aneusomic human cells and of different mouse-human hybrids cells has been compared. G21 trisomic cells are more sensitive than diploid cells; whereas, on the contrary, triploid cells are normal in their human interferon sensitivity. Among other aneusomic cell lines tested, E16 trisomic cells are significantly less sensitive. These data are in favor of the hypotheses that the G21 chromosome carries genetic information for structural proteins involved in the receptor system for interferon, that there is a regulatory mechanism governing the antiviral state, and that the E16 chromosome is a possible candidate for carrying information for such a depressive regulatory mechanism. None of the chromosome abnormalities studies are involved with interferon synthesis.
摘要
已对不同的正常人类细胞、非整倍体人类细胞以及不同的小鼠 - 人类杂交细胞的干扰素敏感性进行了比较。G21三体细胞比二倍体细胞更敏感；而相反，三倍体细胞对人干扰素的敏感性正常。在测试的其他非整倍体细胞系中，E16三体细胞的敏感性明显较低。这些数据支持以下假设：G21染色体携带参与干扰素受体系统结构蛋白的遗传信息，存在一种控制抗病毒状态的调节机制，并且E16染色体可能是携带这种抑制性调节机制信息的候选者。所研究的染色体异常均与干扰素合成无关。
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2
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Ann Hum Genet. 1973 Jan;36(3):273-84. doi: 10.1111/j.1469-1809.1973.tb00590.x.
3
Growth characteristics of human embryonic cell lines with chromosomal anomalies.
Biomedicine. 1974 May 20;21(5):233-6.
4
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