Schultz S G
Fed Proc. 1979 May;38(6):2024-9.
An equivalent electrical circuit model for Na transport across epithelial tissues under steady-state conditions, which incorporates the flows and forces across the two limiting membranes and the paracellular pathway, is described. The analysis of electrophysiologic data obtained on rabbit colon within the framework of this model provides information regarding the thermodynamic activity of cell Na and the resistance offered by the mucosal membrane to Na entry. The interpretation of the data dealing with the active extrusion of Na from the cell across the basolateral membrane awaits more detailed information regarding the pump mechanism responsible for this movement; until then, the electromotive force across the basolateral membrane and the resistance of that barrier must be considered phenomenologic parameters that relate the Na current to the observed electrical potential difference.
本文描述了一种用于描述稳态条件下钠跨上皮组织转运的等效电路模型，该模型纳入了跨两个限制膜以及细胞旁途径的流量和驱动力。在该模型框架内对兔结肠获得的电生理数据进行分析，可提供有关细胞内钠的热力学活性以及黏膜膜对钠进入所提供阻力的信息。关于钠从细胞通过基底外侧膜的主动排出的数据解读，有待获得有关负责此转运的泵机制的更详细信息；在此之前，基底外侧膜上的电动势和该屏障的电阻必须被视为将钠电流与观测到的电位差相关联的唯象参数。
