Schweditsch M O, Dubin N H, Jones G S, Wentz A C
Fertil Steril. 1979 Mar;31(3):252-7. doi: 10.1016/s0015-0282(16)43870-7.
The hormonal profiles of six pregnancies which terminated in miscarriage with the blighted ovum syndrome have been studied and compared with those of a group of patients similarly studied who had clinically normal pregnancies terminating in live birth at term. The serum chorionic gonadotropin (HCG) values were below normal or at the lowest limit of normal in five of six patients. Three patients had progesterone values within 1 SD of the normal, with normal serum estradiol values. It was concluded that the hormonal profile of early pregnancy is characterized by rising serum HCG and estradiol levels and a declining serum progesterone level from the 5th to the 8th week. The theoretical explanation for the dichotomy seems to be that the fetal adrenal anlagen, even at this early embryonic stage, can produce steroid precursors which are aromatized to estradiol. The production of progesterone, however, does not seem to be possible. Abnormal serum estradiol levels strongly suggest the absence of fetal development and a blighted ovum. However, no single hormonal level will distinguish between blighted ovum and potentially salvagable threatened abortion.
对6例因空卵综合征而流产的妊娠的激素水平进行了研究，并与一组同样进行研究的、临床上正常妊娠并足月分娩活婴的患者的激素水平进行了比较。6例患者中有5例血清绒毛膜促性腺激素（HCG）值低于正常或处于正常最低限。3例患者的孕酮值在正常的1个标准差范围内，血清雌二醇值正常。得出的结论是，妊娠早期的激素特征是血清HCG和雌二醇水平升高，而血清孕酮水平从第5周到第8周下降。这种二分法的理论解释似乎是，即使在这个早期胚胎阶段，胎儿肾上腺原基也能产生被芳香化为雌二醇的类固醇前体。然而，孕酮的产生似乎是不可能的。血清雌二醇水平异常强烈提示胎儿发育缺失和空卵。然而，没有单一的激素水平能够区分空卵和有可能挽救的先兆流产。
