自发性高血压、正常血压和低血压大鼠的血管反应性
Vascular reactivity in spontaneously hypertensive normotensive and hypotensive rats.
作者信息
Dupont J, Sassard J
出版信息
Br J Pharmacol. 1974 Feb;50(2):185-8. doi: 10.1111/j.1476-5381.1974.tb08560.x.
Abstract
1 Three strains of rats spontaneously hypertensive (HRS), normotensive (NS) and hypotensive (HOS), were selected by repeated inbreeding.2 In order to explain the different blood pressure levels observed, we have studied their vascular reactivity to noradrenaline and angiotensin II. Experiments were performed in anaesthetized ganglion-blocked, vagotomized rats.3 The reactivity to noradrenaline was significantly higher in HRS than in NS and HOS rats.4 The reactivity to angiotensin II appeared identical in the three strains used.
摘要
1 通过反复近亲繁殖，挑选出了三种品系的大鼠：自发性高血压大鼠（HRS）、正常血压大鼠（NS）和低血压大鼠（HOS）。
2 为了解释观察到的不同血压水平，我们研究了它们对去甲肾上腺素和血管紧张素II的血管反应性。实验在麻醉、阻断神经节并切断迷走神经的大鼠身上进行。
3 HRS大鼠对去甲肾上腺素的反应性显著高于NS和HOS大鼠。
4 所用的三个品系对血管紧张素II的反应性似乎相同。
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