自发性高血压大鼠和正常血压大鼠灌注血管床的血管反应性
Vascular reactivity of perfused vascular bed in spontaneously hypertensive and normotensive rats.
作者信息
Bhattacharya B K, Dadkar N K, Dohadwalla A N
出版信息
Br J Pharmacol. 1977 Feb;59(2):243-6. doi: 10.1111/j.1476-5381.1977.tb07485.x.
Abstract
1 Hypertensive and normotensive rats of the same age group were isolated from an inbred colony of spontaneously hypertensive rats. 2 The perfused hindquarter and mesenteric artery preparations obtained from hypertensive and normotensive rats exhibited an increased reactivity to noradrenaline (NA) and angiotensin II. 3 Dose-response curves to NA obtained from hypertensive and normotensive rats exhibited a steeper slope and higher maximum than those from control rats. 4 These findings suggest that increased vascular reactivity of blood vessels is independent of the development or maintenance of elevated blood pressure.
摘要
从一个近交系自发性高血压大鼠群体中分离出同一年龄组的高血压大鼠和血压正常大鼠。
从高血压大鼠和血压正常大鼠获得的灌注后肢和肠系膜动脉制剂对去甲肾上腺素（NA）和血管紧张素II的反应性增加。
高血压大鼠和血压正常大鼠对NA的剂量-反应曲线比对照大鼠的曲线斜率更陡，最大值更高。
这些发现表明血管反应性增加与血压升高的发生或维持无关。
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