甲状旁腺切除术对盐皮质激素诱导性高血压大鼠心血管反应性的影响。
Effect of parathyroidectomy on cardiovascular reactivity in rats with mineralocorticoid-induced hypertension.
作者信息
Berthelot A, Gairard A
出版信息
Br J Pharmacol. 1978 Feb;62(2):199-205. doi: 10.1111/j.1476-5381.1978.tb08446.x.
Previous work has shown that parathyroidectomy protected Sprague-Dawley rats against mineralocorticoid hypertension. 2 In order to explain this protection, we studied vascular reactivity to noradrenaline and angiotensin II in several groups of rats with and without their parathyroid and thyroid glands. Work was performed in vagotomized, anaesthetized rats after ganglionic blockade with pentolinium, and atropine sulphate. 3 The reactivity to noradrenaline was significantly lower in parathyroidectomized rats, especially at the beginning of mineralocorticoid treatment. 4 Autotransplantation of parathyroid glands in thyroparathyroidectomized rats re-established normal cardiovascular reactivity and development of hypertension. 5 Cardiovascular reactivity to angiotensin II was not affected in parathyroidectomized rats and was lowered in thyroparathyroidectomized thyroxine-treated rats.
先前的研究表明，甲状旁腺切除术可保护斯普拉格-道利大鼠免受盐皮质激素性高血压的影响。为了解释这种保护作用，我们研究了几组有或没有甲状旁腺和甲状腺的大鼠对去甲肾上腺素和血管紧张素II的血管反应性。实验在经喷托铵和硫酸阿托品进行神经节阻断后，处于迷走神经切断、麻醉状态的大鼠身上进行。甲状旁腺切除的大鼠对去甲肾上腺素的反应性显著降低，尤其是在盐皮质激素治疗开始时。在甲状腺甲状旁腺切除的大鼠中进行甲状旁腺自体移植可恢复正常的心血管反应性和高血压的发展。甲状旁腺切除的大鼠对血管紧张素II的心血管反应性未受影响，而在甲状腺甲状旁腺切除并接受甲状腺素治疗的大鼠中则降低。
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