多发性硬化症患者脑脊液和血清样本中针对不同病毒的抗体比较。
Comparison of antibodies against different viruses in cerebrospinal fluid and serum samples from patients with multiple sclerosis.
作者信息
Norrby E, Link H, Olsson J E, Panelius M, Salmi A, Vandvik B
出版信息
Infect Immun. 1974 Oct;10(4):688-94. doi: 10.1128/iai.10.4.688-694.1974.
The occurrence of a local production in the central nervous system (CNS) of antibodies against different selected viruses was analyzed by comparison of titers in serum and cerebrospinal fluid samples from groups of 50 patients with multiple sclerosis from Finland, Norway, and Sweden. Measles antibodies were determined in hemagglutination inhibition, hemolysis inhibition, and nucleocapsid complement fixation tests; mumps, parainfluenza virus type 1, and rubella virus antibodies were determined in hemagglutination inhibition tests; and herpes simplex virus type 1 antibodies were determined in passive hemagglutination tests. For reference purposes tests were also made for adenovirus antibodies in penton hemagglutination enhancement tests and poliovirus antibodies in neutralization enhancement tests. Among the 150 multiple sclerosis patients, a local production of antibodies against measles virus was found in the CNS in 57%, against rubella virus in 19%, mumps virus in 15%, herpes simplex virus type 1 in 11%, and parainfluenza virus type 1 (Sendai) in 3%. A local production in the CNS of antibodies against any of the viruses studied was found in 71% of multiple sclerosis patients. These included 48, 16, and 7% that produced antibodies to one, two, and three or more viruses, respectively.
通过比较来自芬兰、挪威和瑞典的50例多发性硬化症患者组的血清和脑脊液样本中的抗体滴度，分析了中枢神经系统（CNS）中针对不同选定病毒的抗体的局部产生情况。在血凝抑制、溶血抑制和核衣壳补体结合试验中测定麻疹抗体；在血凝抑制试验中测定腮腺炎、1型副流感病毒和风疹病毒抗体；在被动血凝试验中测定1型单纯疱疹病毒抗体。作为参考，还在五聚体血凝增强试验中检测腺病毒抗体，在中和增强试验中检测脊髓灰质炎病毒抗体。在150例多发性硬化症患者中，中枢神经系统中发现针对麻疹病毒的抗体局部产生的占57%，针对风疹病毒的占19%，针对腮腺炎病毒的占15%，针对1型单纯疱疹病毒的占11%，针对1型副流感病毒（仙台株）的占3%。71%的多发性硬化症患者中枢神经系统中发现针对所研究的任何一种病毒的抗体局部产生。其中分别有48%、16%和7%的患者产生针对一种、两种和三种或更多种病毒的抗体。
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