Nikoskelainen E, Nikoskelainen J, Salmi A A, Halonen P E
Acta Neurol Scand. 1975 May;51(5):347-64. doi: 10.1111/j.1600-0404.1975.tb01375.x.
Virus antibody levels were studied in the cerebrospinal fluid (CSF) of 58 patients with optic neuritis and 58 control patients with no indication of multiple sclerosis (MS) or infectious disorders of the central nervous system (CNS). The specimens were tested against three different structural components of measles virus with measles hemagglutination inhibition (HI), measles hemolysis inhibition (HLI) and gel precipitation (GP) tests. Measles antibodies occurred in 62 per cent of CSF specimens from patients with optic neuritis, and 21 per cent of the controls. In the specimens from patients with optic neuritis, the positive rate figures were: for rubella HI test 35, parainfluenza-1 HI 16, and Epstein-Barr virus immunofuorescence (IF) 53 per cent. The frequencies in the control group were 10, 10 and 26 per cent, respectively. Serum/CSF antibody ratios below 80 occurred in measles tests in 45 per cent of patients with optic neuritis and 16 per cent of the control group. Some patients with optic neuritis (but none from the control group) had a reduced serum/CSF antibody ratio in more than one measles antibody test, The patients with optic neuritis had a higher frequency of low serum/CSF albumin ratios indicating blood brain barrier damage, There were, however, several patients with a normal serum/CSF albumin ratio but low serum/CSF immunoglobulin G and measles antibody ratios. This supports the hypothesis that local production of measles antibodies takes place in CNS in some patients with optic neuritis as well as in MS patients. The CSF specimens were further tested against 12 other viruses and mycoplasma pneumoniae complement fixation, but there were no positive specimens. New CSF specimens were taken from five patients during optic neuritis, and from seven patients later on during the follow-up because of the appearance of new neurological symptoms. There were no changes in virus antibody levels, except for two patients with an increase of measles virus antibody titres.
对58例视神经炎患者及58例无多发性硬化（MS）或中枢神经系统（CNS）感染性疾病迹象的对照患者的脑脊液（CSF）中的病毒抗体水平进行了研究。使用麻疹血凝抑制（HI）、麻疹溶血抑制（HLI）和凝胶沉淀（GP）试验，针对麻疹病毒的三种不同结构成分对标本进行检测。视神经炎患者的脑脊液标本中62%出现麻疹抗体，对照组为21%。在视神经炎患者的标本中，阳性率数据如下：风疹HI试验为35%，副流感病毒1型HI为16%，爱泼斯坦-巴尔病毒免疫荧光（IF）为53%。对照组中的频率分别为10%、10%和26%。在麻疹试验中，45%的视神经炎患者和16%的对照组血清/脑脊液抗体比率低于80。一些视神经炎患者（但对照组中没有）在不止一项麻疹抗体试验中血清/脑脊液抗体比率降低。视神经炎患者血清/脑脊液白蛋白比率低表明血脑屏障受损的频率更高。然而，有几位患者血清/脑脊液白蛋白比率正常，但血清/脑脊液免疫球蛋白G和麻疹抗体比率较低。这支持了这样一种假设，即在一些视神经炎患者以及MS患者中，中枢神经系统会局部产生麻疹抗体。对脑脊液标本进一步针对其他12种病毒和肺炎支原体进行补体结合试验，但没有阳性标本。在视神经炎期间从5例患者身上采集了新的脑脊液标本，在随访期间由于出现新的神经症状又从7例患者身上采集了新的脑脊液标本。除了2例麻疹病毒抗体滴度升高的患者外，病毒抗体水平没有变化。
