Elevated antibody levels against measles virus P protein in sera of patients with multiple sclerosis.

Immune precipitation followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and densitometry was used to estimate immunoglobulin G antibody levels against the H, P, and M proteins of measles virus in the sera of 24 patients with multiple sclerosis and 24 serologically matched controls. Of the 24 multiple sclerosis sera, 5 showed a statistically significant increase in antibody titer to the P protein as compared with the control sera. Antibody titers to the H and M proteins in multiple sclerosis and control sera were not significantly different.