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Molecular weight of two oncornavirus genomes: derivation from particle molecular weights and RNA content.两种肿瘤病毒基因组的分子量：从病毒颗粒分子量和RNA含量推导而来。
J Virol. 1974 Dec;14(6):1388-93. doi: 10.1128/JVI.14.6.1388-1393.1974.
2
Correlation of RNA binding affinity of avian oncornavirus p19 proteins with the extent of processing of virus genome RNA in cells.禽肿瘤病毒p19蛋白的RNA结合亲和力与细胞中病毒基因组RNA加工程度的相关性。
J Virol. 1980 Sep;35(3):722-31. doi: 10.1128/JVI.35.3.722-731.1980.
3
Ribonucleotide sequence homology among avian oncornaviruses.禽肿瘤病毒之间的核糖核苷酸序列同源性。
J Virol. 1975 Jan;17(1):106-113. doi: 10.1128/JVI.17.1.106-113.1976.
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The nucleic acid from avian myeloblastosis virus compared with the RNA from the Bryan strain of Rous sarcoma virus.将禽成髓细胞瘤病毒的核酸与劳氏肉瘤病毒Bryan株的RNA进行比较。
Proc Natl Acad Sci U S A. 1965 Dec;54(6):1686-92. doi: 10.1073/pnas.54.6.1686.
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Hydrodynamic diameters of murine mammary, Rous sarcoma, and feline leukemia RNA tumor viruses: studies by laser beat frequency light-scattering spectroscopy and electron microscopy.鼠乳腺、劳氏肉瘤和猫白血病RNA肿瘤病毒的流体动力学直径：激光拍频光散射光谱法和电子显微镜研究
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Proc Natl Acad Sci U S A. 1975 Sep;72(9):3716-20. doi: 10.1073/pnas.72.9.3716.
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Hydrodynamic diameters of RNA tumor viruses. Studies by laser beat frequency light scattering spectroscopy of avian myeloblastosis and Rauscher murine leukemia viruses.RNA肿瘤病毒的流体动力学直径。通过激光拍频光散射光谱法对禽成髓细胞瘤病毒和劳舍尔小鼠白血病病毒的研究。
Biochemistry. 1975 Jan 14;14(1):134-41. doi: 10.1021/bi00672a023.
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Extensive in vitro transcription of rous sarcoma virus RNA by avian myeloblastosis virus DNA polymerase and concurrent activation of the associated RNase H.禽成髓细胞瘤病毒DNA聚合酶对劳氏肉瘤病毒RNA进行广泛的体外转录，并同时激活相关的核糖核酸酶H。
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Amino-terminal amino acid sequence of p10, the fifth major gag polypeptide of avian sarcoma and leukemia viruses.禽肉瘤和白血病病毒的第五种主要gag多肽p10的氨基末端氨基酸序列。
J Virol. 1983 Feb;45(2):885-8. doi: 10.1128/JVI.45.2.885-888.1983.

引用本文的文献

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Selective packaging of host tRNA's by murine leukemia virus particles does not require genomic RNA.小鼠白血病病毒颗粒对宿主tRNA的选择性包装不需要基因组RNA。
J Virol. 1979 Jan;29(1):328-35. doi: 10.1128/JVI.29.1.328-335.1979.
2
Configurational variants of oncornavirus RNAs.肿瘤病毒RNA的构型变体
J Virol. 1976 Sep;19(3):810-9. doi: 10.1128/JVI.19.3.810-819.1976.

本文引用的文献

1
Virus of avian myeloblastosis. XII. Chemical constitution.禽成髓细胞瘤病毒。十二、化学组成。
J Natl Cancer Inst. 1959 Jul;23(1):183-97.
2
Virus of avian erythromyeloblastic leukosis. IV. Sedimentation, density and hydration.禽红细胞成髓细胞白血病病毒。IV. 沉降、密度与水合作用
Biochim Biophys Acta. 1954 May;14(1):12-7. doi: 10.1016/0006-3002(54)90124-9.
3
Molecular weights of coliphages and colip- hage DNA. II. Measurement of diffusion coefficients using optical mixing spectroscopy, and measurement of sedimentation coefficients.大肠杆菌噬菌体和大肠杆菌噬菌体DNA的分子量。II. 使用光学混合光谱法测量扩散系数以及测量沉降系数。
J Mol Biol. 1970 Dec 28;54(3):547-56. doi: 10.1016/0022-2836(70)90125-7.
4
Hydrogen exchange in proteins.蛋白质中的氢交换
Adv Protein Chem. 1966;21:287-386. doi: 10.1016/s0065-3233(08)60129-1.
5
Sedimentation equilibrium analysis of the molecular weight of a tumor virus RNA.肿瘤病毒RNA分子量的沉降平衡分析
Virology. 1971 Sep;45(3):782-7. doi: 10.1016/0042-6822(71)90195-4.
6
Intensity fluctuation spectroscopy of laser light scattered by solutions of spherical viruses: R17, Q beta, BSV, PM2, and T7. II. Diffusion coefficients, molecular weights, solvation, and particle dimensions.球形病毒（R17、Qβ、BSV、PM2和T7）溶液散射激光的强度涨落光谱学：II. 扩散系数、分子量、溶剂化作用及颗粒尺寸
Biochemistry. 1974 Feb 26;13(5):960-70. doi: 10.1021/bi00702a021.
7
Intensity fluctuation spectroscopy of laser light scattered by solutions of spherical viruses: R17, Q beta, BSV, PM2, and T7. I. Light-scattering technique.球形病毒（R17、Qβ、BSV、PM2和T7）溶液散射激光的强度涨落光谱学。I. 光散射技术。
Biochemistry. 1974 Feb 26;13(5):952-60. doi: 10.1021/bi00702a020.
8
Molecular weight determination of Sendai and Newcastle disease virus RNA.仙台病毒和新城疫病毒RNA的分子量测定
J Virol. 1974 Feb;13(2):261-8. doi: 10.1128/JVI.13.2.261-268.1974.
9
Small RNAs of Rous sarcoma virus: characterization by two-dimensional polyacrylamide gel electrophoresis and fingerprint analysis.劳氏肉瘤病毒的小RNA：通过二维聚丙烯酰胺凝胶电泳和指纹分析进行表征
J Virol. 1973 Dec;12(6):1226-37. doi: 10.1128/JVI.12.6.1226-1237.1973.
10
Characterization of the low-molecular-weight RNAs associated with the 70S RNA of Rous sarcoma virus.与劳氏肉瘤病毒70S RNA相关的低分子量RNA的特性分析。
J Virol. 1973 Aug;12(2):334-42. doi: 10.1128/JVI.12.2.334-342.1973.

两种肿瘤病毒基因组的分子量：从病毒颗粒分子量和RNA含量推导而来。

Molecular weight of two oncornavirus genomes: derivation from particle molecular weights and RNA content.

作者信息

Bellamy A R, Gillies S C, Harvey J D

出版信息

J Virol. 1974 Dec;14(6):1388-93. doi: 10.1128/JVI.14.6.1388-1393.1974.

DOI:10.1128/JVI.14.6.1388-1393.1974
PMID:4372402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC355666/
Abstract

Sedimentation analysis and intensity fluctuation spectroscopy have been used in conjunction with the Svedberg equation to determine the particle molecular weights of Rous sarcoma virus (Prague strain) and avian myeloblastosis virus (BAI strain). The molecular weights of these two viruses are (294 +/- 20) x 10(6) and (256 +/- 18) x 10(6), respectively. Values for the molecular weight of the RNA contained in each particle have been calculated as (5.58 +/- 0.5) x 10(6) and (5.88 +/- 0.5) x 10(6). Since the proportion of the viral RNA represented by 4 to 7S low-molecular-weight material is known, the molecular weight of the 60 to 70S genomes may be calculated to lie in the range (3.8 +/- 0.3 to 4.8 +/- 0.4) x 10(6) for both particles. These estimates for the molecular weight of the 60 to 70S genome are much lower than previous estimates and fall within the range of current estimates of the size of a single 35S subunit. The implications of this finding are discussed in terms of current theories for the structure of the genome of RNA tumor viruses.

摘要

沉降分析和强度波动光谱法已与斯维德伯格方程结合使用，以确定劳氏肉瘤病毒（布拉格株）和禽成髓细胞瘤病毒（BAI株）的颗粒分子量。这两种病毒的分子量分别为(294±20)×10⁶和(256±18)×10⁶。每个颗粒中所含RNA的分子量值经计算分别为(5.58±0.5)×10⁶和(5.88±0.5)×10⁶。由于已知4至7S低分子量物质所代表的病毒RNA比例，因此对于两种颗粒，60至70S基因组的分子量经计算在(3.8±0.3至4.8±0.4)×10⁶范围内。这些对60至70S基因组分子量的估计远低于先前的估计，且落在当前对单个35S亚基大小估计的范围内。根据RNA肿瘤病毒基因组结构的当前理论，讨论了这一发现的意义。