Gazit A, Eylan E, Rosen N, Samucha R
Exp Cell Biol. 1979;47(1):29-42. doi: 10.1159/000162920.
Sequential intraperitoneal administration of a low molecular-weight-enhancing factor, isolated from egg fluids, in mice infected with Rauscher leukemia virus (RLV) significantly stimulated viral replication. This was evidenced by elevated levels of viral DNA-polymerase in mouse sera. This stimulation of viral replication correlated with aggrevation of viral leukemogenicity, as reflected by increment of splenomegalic response and shortening of survival time. The in vivo potentiation of replication and leukemogenicity of RLV is achieved at least partly by the enhancing factor at the cellular level, since RLV replication was found to be stimulated also in an in vitro system. We assume that the stimulatory effect of the enhancing factor on viral replication is connected with its stimulatory effect on the synthesis of cellular DNA.
从蛋清液中分离出的低分子量增强因子对感染劳斯氏白血病病毒（RLV）的小鼠进行腹腔内连续给药，可显著刺激病毒复制。小鼠血清中病毒DNA聚合酶水平升高证明了这一点。病毒复制的这种刺激与病毒致白血病性的加重相关，表现为脾肿大反应增强和存活时间缩短。RLV复制和致白血病性的体内增强至少部分是由细胞水平的增强因子实现的，因为在体外系统中也发现RLV复制受到刺激。我们假设增强因子对病毒复制的刺激作用与其对细胞DNA合成的刺激作用有关。
