仔猪胃肠道中的肠道病毒中和活性。
Enterovirus neutralizing activity in the gastrointestinal tract of piglets.
作者信息
Derbyshire J B
出版信息
Can J Comp Med. 1974 Oct;38(4):425-9.
Neutralizing activity against porcine enterovirus strain T80 was demonstrated in the contents of the stomach, duodenum or ileum of four piglets which were suckling dams whose milk contained neutralizing substances against the same virus. No neutralizing activity was detected in the gastrointestinal contents of an unsuckled piglet or in four weaned piglets. Extracts of intestinal tissue from each of the above piglets failed to neutralize the virus. Four weaned piglets were dosed orally with live T80 virus. From nine days after infection virus neutralizing activity was found in extracts of tissue prepared from the duodenum, jejunum, ileum, caecum and colon but not in the contents of the gastrointestinal tract and a serological response to the virus was demonstrated. No virus neutralizing activity was detected in gastrointestinal tissue or contents from four weaned piglets inoculated parenterally with live T80 virus or in four piglets dosed orally with inactivated T80 virus and these piglets did not respond serologically to the virus.
在四只哺乳仔猪的胃、十二指肠或回肠内容物中，发现了针对猪肠道病毒T80株的中和活性，这些仔猪所哺乳的母猪乳汁中含有针对同一病毒的中和物质。在一只未哺乳仔猪或四只断奶仔猪的胃肠道内容物中未检测到中和活性。上述每只仔猪的肠道组织提取物均未中和该病毒。给四只断奶仔猪口服活T80病毒。感染后九天，在十二指肠、空肠、回肠、盲肠和结肠制备的组织提取物中发现了病毒中和活性，但在胃肠道内容物中未发现，并且证明了对该病毒的血清学反应。在经肌肉注射接种活T80病毒的四只断奶仔猪的胃肠道组织或内容物中，或在口服接种灭活T80病毒的四只仔猪中，均未检测到病毒中和活性，并且这些仔猪对该病毒没有血清学反应。
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