用猪肠道病毒接种的猪体内局部和全身病毒中和活性的表征
Characterization of the local and systemic virus neutralizing activity in swine vaccinated with a porcine enterovirus.
作者信息
Hazlett D T, Derbyshire J B
出版信息
Can J Comp Med. 1977 Jul;41(3):257-63.
The virus neutralizing substance in the gastrointestinal tract of swine vaccinated in different ways with porcine enterovirus strain T80 was characterized by tests for enhancement and absorption of virus neutralizing activity by class specific antiporcine Ig antisera. The gastrointestinal virus neutralizing activity of piglets which were vaccinated with live virus orally resided predominantly in the IgA class, although some activity was present also in the IgM and IgG classes. The serum virus neutralizing activity of this group was present in all three classes but primarily in the IgG class. The IgA in the serum of this group was presumably of gut origin. However, in piglets vaccinated with live virus intramuscularly, with formaldehyde-inactivated virus orally or intramuscularly or with ethylenimine-inactivated virus by both oral and subcutaneous routes, both serum and gastrointestinal virus neutralizing activity were attributable predominantly to antibodies of the IgG and IgM classes. None possessed serum IgA. There was evidence also for the presence of Ig fragments in some gastrointestinal extracts.
用猪肠道病毒T80株以不同方式接种疫苗的猪胃肠道中的病毒中和物质，通过用类特异性抗猪Ig抗血清进行病毒中和活性的增强和吸收试验来表征。口服活病毒接种的仔猪胃肠道病毒中和活性主要存在于IgA类中，尽管IgM和IgG类中也存在一些活性。该组的血清病毒中和活性在所有三类中均存在，但主要存在于IgG类中。该组血清中的IgA可能来源于肠道。然而，在肌肉注射活病毒、口服或肌肉注射甲醛灭活病毒或通过口服和皮下途径注射乙烯亚胺灭活病毒的仔猪中，血清和胃肠道病毒中和活性主要归因于IgG和IgM类抗体。均无血清IgA。也有证据表明在一些胃肠道提取物中存在Ig片段。
Zotero 插件