Clark A W, Monaco A P
Immunology. 1974 Nov;27(5):887-93.
An injection of a low dose of donor-type bone marrow cells causes specific added survival of skin allografts on antilymphocyte serum (ALS) treated mice over that seen in mice given only ALS. The effects of single injections of Calmette—Guerin (BCG) and were studied at various times in this enhancing system. All three agents abrogated the prolongation when given 5 days after grafting but produced a striking increase in prolongation when given 7 days before skin grafting with ALS and subsequent bone marrow. This effect was not found with BCG or . The unique graft-prolonging ability of may be related to the changes it produces in the regional nodes.
注射低剂量供体型骨髓细胞可使抗淋巴细胞血清(ALS)处理的小鼠皮肤同种异体移植物的存活时间比仅接受ALS处理的小鼠显著延长。在这个增强系统中,我们在不同时间研究了单次注射卡介苗(BCG)和[此处原文缺失一种试剂名称]的效果。当在移植后5天给予这三种试剂时,它们都消除了移植物存活时间的延长,但当在皮肤移植前7天与ALS及随后的骨髓一起给予时,[此处原文缺失一种试剂名称]显著延长了移植物的存活时间。BCG或[此处原文缺失一种试剂名称]未发现这种效果。[此处原文缺失一种试剂名称]独特的移植物延长能力可能与其在局部淋巴结产生的变化有关。