Nomoto K, Harada T, Koyanagi R, Hosoi M, Takeya K
Jpn J Microbiol. 1976 Oct;20(5):375-84. doi: 10.1111/j.1348-0421.1976.tb01003.x.
Enhancing and suppressing effects of microbial adjuvants were studied in female mice of the C3H/He, AKR and SL strains. Propionibacterium acnes, Bordetella pertussis, BCG and yeast cell wall (YCW) were chosen as adjuvants. As antigens, we chose hamster erythrocytes (HRBC) which proved to be a weak antigen for mice. Adjuvants were given on day --7, day 0 or day 3, and HRBC were injected on day 0. The results were as follows. 1) P. acnes facilitated IgM and IgG antibody production in AKR mice and suppressed IgM antibody production in SL mice, when given on day --7. When P. acnes was given on day 0, they suppressed IgM antibody production in all of the strains used. 2) When B. pertussis was given on day 0, it exhibited enhancing effects on IgG antibody production in all of the strains and a suppressing effect on IgM antibody production in SL mice. 3) BCG suppressed IgM antibody production in all strains when given on day 0. 4) YCW showed no influence on antibody production in any combination used in this work. 5) SL mice were very sensitive to suppressing effects by adjuvants. Strain differences in the expression of enhancing and suppressing effects by adjuvants appear to be under some control independent of antigen-specific immune response genes.
在C3H/He、AKR和SL品系的雌性小鼠中研究了微生物佐剂的增强和抑制作用。选择痤疮丙酸杆菌、百日咳博德特氏菌、卡介苗和酵母细胞壁（YCW）作为佐剂。作为抗原，我们选择了仓鼠红细胞（HRBC），事实证明其对小鼠来说是一种弱抗原。在第-7天、第0天或第3天给予佐剂，并在第0天注射HRBC。结果如下。1）当在第-7天给予痤疮丙酸杆菌时，其促进了AKR小鼠中IgM和IgG抗体的产生，并抑制了SL小鼠中IgM抗体的产生。当在第0天给予痤疮丙酸杆菌时，其抑制了所有所用品系中IgM抗体的产生。2）当在第0天给予百日咳博德特氏菌时，其对所有品系中IgG抗体的产生均表现出增强作用，而对SL小鼠中IgM抗体的产生有抑制作用。3）当在第0天给予卡介苗时，其抑制了所有品系中IgM抗体的产生。4）在本研究中使用的任何组合中，酵母细胞壁对抗体产生均无影响。5）SL小鼠对佐剂的抑制作用非常敏感。佐剂增强和抑制作用表达中的品系差异似乎受某种独立于抗原特异性免疫反应基因的调控。
