Youngner J S, Keleti G, Feingold D S
Infect Immun. 1974 Dec;10(6):1202-6. doi: 10.1128/iai.10.6.1202-1206.1974.
Extraction of living Brucella abortus (strain 456) with aqueous ether yielded a nonviable, insoluble residue (Bru-Pel). When injected into mice, Bru-Pel was an effective, nontoxic interferon stimulus. Mice pretreated with Bru-Pel were protected against challenge with otherwise lethal doses of Semliki Forest virus. Significant protection was afforded when Bru-Pel was given as many as 7 days before virus challenge. Evidence is presented dealing with the complex nature of Bru-Pel and with the possibility that the antiviral activity of Bru-Pel may be associated not only with the production of interferon, but with a general increase in the level of nonspecific resistance in animals.
用水性乙醚提取活布鲁氏菌流产菌株（456株），得到一种无活力的不溶性残渣（布鲁氏菌-佩尔）。将布鲁氏菌-佩尔注射到小鼠体内时，它是一种有效的无毒干扰素刺激物。用布鲁氏菌-佩尔预处理的小鼠可免受致死剂量的Semliki森林病毒攻击。在病毒攻击前多达7天给予布鲁氏菌-佩尔，可提供显著的保护作用。文中提供的证据涉及布鲁氏菌-佩尔的复杂性质，以及布鲁氏菌-佩尔的抗病毒活性可能不仅与干扰素的产生有关，还与动物非特异性抵抗力水平的普遍提高有关的可能性。
