The Queensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia.
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Nat Commun. 2022 Feb 16;13(1):895. doi: 10.1038/s41467-022-28299-4.
Habituation is a form of learning during which animals stop responding to repetitive stimuli, and deficits in habituation are characteristic of several psychiatric disorders. Due to technical challenges, the brain-wide networks mediating habituation are poorly understood. Here we report brain-wide calcium imaging during larval zebrafish habituation to repeated visual looming stimuli. We show that different functional categories of loom-sensitive neurons are located in characteristic locations throughout the brain, and that both the functional properties of their networks and the resulting behavior can be modulated by stimulus saliency and timing. Using graph theory, we identify a visual circuit that habituates minimally, a moderately habituating midbrain population proposed to mediate the sensorimotor transformation, and downstream circuit elements responsible for higher order representations and the delivery of behavior. Zebrafish larvae carrying a mutation in the fmr1 gene have a systematic shift toward sustained premotor activity in this network, and show slower behavioral habituation.
习惯化是一种学习形式，在此过程中，动物会停止对重复刺激做出反应，而习惯化缺陷是几种精神疾病的特征。由于技术挑战，介导习惯化的大脑广泛网络还了解甚少。在这里，我们报告了在幼鱼对重复视觉逼近刺激习惯化过程中的大脑全钙成像。我们发现，对逼近敏感的神经元的不同功能类别位于大脑的特征位置，并且其网络的功能特性以及由此产生的行为都可以通过刺激显著性和时间来调节。使用图论，我们确定了一个习惯化最小的视觉回路，一个被认为介导感觉运动转换的中度习惯化中脑群体，以及负责更高阶表示和行为传递的下游回路元件。携带 FMR1 基因突变的斑马鱼幼虫在该网络中表现出持续的前运动活动的系统性转变，并表现出较慢的行为习惯化。
