Ramsey E J, Carey K V, Peterson W L, Jackson J J, Murphy F K, Read N W, Taylor K B, Trier J S, Fordtran J S
Gastroenterology. 1979 Jun;76(6):1449-57.
Seventeen of 37 healthy volunteers participating in studies of acid secretion and 1 patient with Zollinger-Ellison syndrome became rapidly and profoundly hypochlorhydric. A mild illness with epigastric pain occurred in 9 subjects, usually several days before detection of hypochlorhydria. Gastric mucosal biopsy specimens taken from subjects during hypochlorhydria revealed severe fundal and antral gastritis; however, even when acid secretion was severely depressed, parietal cells were abundant and appeared normal histologically. During hypochlorhydria, gastric permeability to hydrogen, sodium, and lithium was normal in 4 subjects. Serum gastrin concentrations were usually normal, whereas serum pepsinogen concentrations were invariably elevated. Serum parietal cell antibodies were not present. Acid secretion returned to near baseline levels in 14 of 17 subjects after a mean of 126 days (range 53--235); severity of gastritis diminished concurrently in 7 of 10 subjects on whom biopsies were serially performed. An infectious etiology is suspected, although serologic studies and bacterial and conventional viral cultures of stool and gastric juice have not identified a candidate agent.
参与胃酸分泌研究的37名健康志愿者中有17名以及1名卓-艾综合征患者迅速且严重胃酸过少。9名受试者出现了伴有上腹部疼痛的轻度疾病，通常在检测到胃酸过少前几天出现。胃酸过少期间从受试者获取的胃黏膜活检标本显示有严重的胃底和胃窦胃炎；然而，即使胃酸分泌严重受抑，壁细胞数量丰富且组织学上看起来正常。胃酸过少期间，4名受试者的胃对氢、钠和锂的通透性正常。血清胃泌素浓度通常正常，而血清胃蛋白酶原浓度总是升高。不存在血清壁细胞抗体。17名受试者中有14名在平均126天（范围为（53-235））后胃酸分泌恢复到接近基线水平；在连续进行活检的10名受试者中有7名同时胃炎严重程度减轻。尽管血清学研究以及粪便和胃液的细菌及传统病毒培养未鉴定出候选病原体，但怀疑有感染性病因。
