Minor T E, Baker J W, Dick E C, DeMeo A N, Ouellette J J, Cohen M, Reed C E
J Pediatr. 1974 Oct;85(4):472-7. doi: 10.1016/s0022-3476(74)80447-6.
A longitudinal clincal and microbiologic surveillance was conducted from October to May, 1971-72, on 16 children with infectious asthma and 15 of their nonasthmatic siblings. Asthmatic children experienced a significantly greater frequency of viral respiratory infections than did nonasthmatic ones (5.1 vs. 3.8 per subject). This increased incidence appeared to be largely the result of a greater number of rhinovirus infections. While respiratory infections of identical etiology that occurred concurrently in an asthmatic and his sibling were equivalent in severity, illnesses were longer (but not significantly so) in asthmatic children.
1971年10月至1972年5月，对16名感染性哮喘儿童及其15名非哮喘兄弟姐妹进行了纵向临床和微生物学监测。哮喘儿童发生病毒性呼吸道感染的频率明显高于非哮喘儿童（每位受试者分别为5.1次和3.8次）。这种发病率的增加似乎主要是鼻病毒感染数量较多的结果。虽然哮喘儿童及其兄弟姐妹同时发生的病因相同的呼吸道感染严重程度相当，但哮喘儿童的病程较长（但差异不显著）。
