核黄素缺乏大鼠的肝脏药物羟化作用和脂质过氧化作用。
Hepatic drug hydroxylation and lipid peroxidation in riboflavin-deficient rats.
作者信息
Patel J M, Galdhar N R, Pawar S S
出版信息
Biochem J. 1974 Jun;140(3):363-8. doi: 10.1042/bj1400363.
The effect of riboflavin deficiency and phenobarbital pretreatment on drug hydroxylation and lipid peroxidation was investigated. A significant decrease in aniline and acetanilide hydroxylation as well as NADPH-linked and ascorbate-induced lipid peroxidation was observed during 4- and 7-week riboflavin deficiency in both adult male and adult female rats. The drug-hydroxylation and lipid-peroxidation activities were further lowered with the increase in riboflavin deficiency. The phenobarbital pretreatment induced aniline and acetanilide hydroxylase activity even in riboflavin-deficient animals. Drug hydroxylation inhibits lipid peroxidation in both deficient and normal rats. The administration of riboflavin was followed by a significant increase in drug hydroxylation and lipid peroxidation.
研究了核黄素缺乏和苯巴比妥预处理对药物羟化作用及脂质过氧化的影响。在成年雄性和成年雌性大鼠4周和7周核黄素缺乏期间，观察到苯胺和乙酰苯胺羟化作用以及NADPH相关和抗坏血酸诱导的脂质过氧化显著降低。随着核黄素缺乏程度的增加，药物羟化和脂质过氧化活性进一步降低。即使在核黄素缺乏的动物中，苯巴比妥预处理也能诱导苯胺和乙酰苯胺羟化酶活性。药物羟化在缺乏和正常大鼠中均抑制脂质过氧化。给予核黄素后，药物羟化和脂质过氧化显著增加。
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