大鼠肝微粒体部分中苯巴比妥诱导细胞色素P-450所需的膳食脂质。

Marshall W J, McLean A E

Biochem J. 1971 May;122(4):569-73. doi: 10.1042/bj1220569.

Rats fed on purified synthetic diets have a markedly lower cytochrome P-450 concentration and hydroxylating enzyme activity in liver microsomal fraction than rats fed on stock pellets. 2. When both groups are treated with phenobarbitone the difference is even greater, the purified diet allowing only 50% of the cytochrome P-450 concentrations of controls. 3. Addition of herring oil, linoleic acid or 0.1% oxidized sitosterol to the diets allows induction of cytochrome P-450 to take place. 4. Addition of coconut oil to the diet does not permit induction of cytochrome P-450. 5. The interactions between dietary protein and the lipid substances are explored. 6. The mechanism of induction of microsomal hydroxylation enzymes by drugs is discussed in the light of these requirements.

以纯化合成饲料喂养的大鼠，其肝脏微粒体部分的细胞色素P - 450浓度和羟化酶活性明显低于以普通颗粒饲料喂养的大鼠。2. 当两组都用苯巴比妥处理时，差异更大，纯化饲料组的细胞色素P - 450浓度仅为对照组的50%。3. 在饲料中添加鲱鱼油、亚油酸或0.1%氧化甾醇可使细胞色素P - 450得以诱导产生。4. 在饲料中添加椰子油则不能诱导细胞色素P - 450的产生。5. 对膳食蛋白质与脂质物质之间的相互作用进行了研究。6. 根据这些需求，讨论了药物诱导微粒体羟化酶的机制。

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核心技术专利：CN118964589B侵权必究

Marshall W J, McLean A E

Biochem J. 1971 May;122(4):569-73. doi: 10.1042/bj1220569.

Rats fed on purified synthetic diets have a markedly lower cytochrome P-450 concentration and hydroxylating enzyme activity in liver microsomal fraction than rats fed on stock pellets. 2. When both groups are treated with phenobarbitone the difference is even greater, the purified diet allowing only 50% of the cytochrome P-450 concentrations of controls. 3. Addition of herring oil, linoleic acid or 0.1% oxidized sitosterol to the diets allows induction of cytochrome P-450 to take place. 4. Addition of coconut oil to the diet does not permit induction of cytochrome P-450. 5. The interactions between dietary protein and the lipid substances are explored. 6. The mechanism of induction of microsomal hydroxylation enzymes by drugs is discussed in the light of these requirements.

以纯化合成饲料喂养的大鼠，其肝脏微粒体部分的细胞色素P - 450浓度和羟化酶活性明显低于以普通颗粒饲料喂养的大鼠。2. 当两组都用苯巴比妥处理时，差异更大，纯化饲料组的细胞色素P - 450浓度仅为对照组的50%。3. 在饲料中添加鲱鱼油、亚油酸或0.1%氧化甾醇可使细胞色素P - 450得以诱导产生。4. 在饲料中添加椰子油则不能诱导细胞色素P - 450的产生。5. 对膳食蛋白质与脂质物质之间的相互作用进行了研究。6. 根据这些需求，讨论了药物诱导微粒体羟化酶的机制。