体外刺激牛生长激素释放对三磷酸腺苷的需求。
Requirement for adenosine triphosphate for stimulation in vitro of ox growth-hormone release.
作者信息
McPherson M, Schofield J G
出版信息
Biochem J. 1974 Jun;140(3):479-85. doi: 10.1042/bj1400479.
Abstract
Rotenone, carbonyl cyanide chloromethoxyphenylhydrazone and 2,4-dinitrophenol cause parallel falls in ox pituitary ATP content and growth-hormone release in the presence of 65mm-K(+). Carbonyl cyanide chloromethoxyphenylhydrazone (0.4mug/ml) prevented the rise in growth-hormone release, but not the rise in 3':5'-cyclic AMP content after addition of prostaglandin E(2) (1mug/ml). The rate of hormone release from unstimulated slices and from slices in the presence of Ba(2+) at 2.3 or 6.9mm was proportional to the ATP content of the slices. Carbonyl cyanide chloromethoxyphenylhydrazone at concentrations that inhibited release in the presence of the three secretagogues did not alter the pituitary contents of Na(+), K(+) or Ca(2+). The implications of these observations are discussed in terms of the mechanism of stimulus-secretion coupling.
摘要
在存在65mM钾离子的情况下，鱼藤酮、羰基氰化物氯甲氧基苯腙和2,4-二硝基苯酚会使牛垂体中的三磷酸腺苷（ATP）含量和生长激素释放同时下降。羰基氰化物氯甲氧基苯腙（0.4μg/ml）可阻止生长激素释放的增加，但在添加前列腺素E₂（1μg/ml）后，无法阻止3',5'-环磷酸腺苷（cAMP）含量的增加。未受刺激的切片以及在存在2.3或6.9mM钡离子的切片中，激素释放速率与切片中的ATP含量成正比。在存在三种促分泌剂时抑制释放的浓度下，羰基氰化物氯甲氧基苯腙不会改变垂体中钠离子、钾离子或钙离子的含量。根据刺激-分泌偶联机制对这些观察结果的意义进行了讨论。
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