血浆游离脂肪酸对肝脏脂肪生成的调节：脂蛋白分泌、胆固醇合成、酮体生成及糖异生的同步研究
Regulation of hepatic lipogenesis by plasma free fatty acids: simultaneous studies on lipoprotein secretion, cholesterol synthesis, ketogenesis and gluconeogenesis.
作者信息
Mayes P A, Topping D L
出版信息
Biochem J. 1974 Apr;140(1):111-4. doi: 10.1042/bj1400111.
Abstract
- An inverse logarithmic relationship was found between lipogenesis and the concentration of serum free fatty acids perfusing the rat liver. 2. Increased concentrations of serum free fatty acids did not alter cholesterol synthesis, triglyceride secretion or increase gluconeogenesis. 3. No direct relationship was found between ketogenesis and either lipogenesis or gluconeogenesis.
摘要
- 研究发现，大鼠肝脏的脂肪生成与灌注血清游离脂肪酸的浓度之间呈负对数关系。2. 血清游离脂肪酸浓度升高并未改变胆固醇合成、甘油三酯分泌或增加糖异生作用。3. 未发现生酮作用与脂肪生成或糖异生作用之间存在直接关系。
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