Autenrieth W, Neu I
Fortschr Med. 1979 Apr 12;97(14):645-8.
Multiple Sclerosis is one of the most common neurological diseases in North and Central Europe and USA, the prevalence is 0,03-0,06%. The precise aetiological and pathological processes underlying the disease are still unknown. As there is as yet no laboratory test that is specific for Multiple Sclerosis, the diagnosis is still a clinical one. It depends on the history--a majority of patients has a history of remissions--and on the demonstration of objective signs of lesions in the white matter of the central nervous system. There can be found some early symptoms--such as optic neuritis--and some typical combinations of symptoms that make the diagnosis Multiple Sclerosis probable or clinically definit. Among the laboratory tests the investigation of cerebrospinal fluid is most important.
多发性硬化症是北欧、中欧和美国最常见的神经疾病之一，患病率为0.03% - 0.06%。该疾病确切的病因和病理过程仍不清楚。由于目前尚无针对多发性硬化症的特异性实验室检查，诊断仍基于临床判断。这取决于病史——大多数患者有缓解期病史——以及中枢神经系统白质病变客观体征的显示。可发现一些早期症状，如视神经炎，以及一些典型的症状组合，这些使得多发性硬化症的诊断成为可能或临床确诊。在实验室检查中，脑脊液检查最为重要。
